Challenge: Existing large language models (LLMs) are not effective in solving real-world healthcare tasks, but they are able to provide demographic information and provide biased health predictions.
Approach: They evaluate state-of-the-art LLMs with three prevalent learning frameworks across six diverse healthcare tasks and find significant challenges in applying LLM to real-world healthcare tasks.
Outcome: The proposed models perform poorly in real-world healthcare tasks and are inconsistent with existing learning frameworks.

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Missing the Margins: A Systematic Literature Review on the Demographic Representativeness of LLMs (2025.findings-acl)

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Challenge: 211 studies on the demographic representativeness of large language models have conflicting results . 29% of the studies report positive conclusions on the representativeness, 30% do not evaluate LLMs across multiple demographic categories or within demographic subcategories.
Approach: 211 papers review the representativeness of large language models . authors recommend more precise evaluation methods and comprehensive documentation of demographic attributes .
Outcome: 211 studies on the representativeness of large language models are reviewed . 29% of the studies report positive conclusions, but 30% fail to specify subcategories . authors recommend more precise evaluation methods and documentation of demographic attributes .
The Impossibility of Fair LLMs (2025.acl-long)

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Challenge: Existing frameworks for evaluating large language models do not extend to general-purpose AI contexts or are infeasible in practice.
Approach: They analyze a variety of technical fairness frameworks to find inherent challenges . they find that each framework does not logically extend to the general-purpose AI context .
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A Comprehensive Survey on the Trustworthiness of Large Language Models in Healthcare (2025.findings-emnlp)

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Challenge: a survey of large language models in healthcare raises critical concerns around trustworthiness . trustworthy of LLMs in healthcare remains underexplored, lacking a systematic review .
Approach: a new survey examines the trustworthiness of large language models in healthcare . a review examines how each dimension affects reliability and ethical deployment of LLMs .
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Can LLMs Replace Clinical Doctors? Exploring Bias in Disease Diagnosis by Large Language Models (2024.findings-emnlp)

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Challenge: a new study examines the bias of disease prediction in large language models . the model biases are prevalent across gender, age range and disease judgment behaviors .
Approach: They propose a prompt-based approach to alleviate the bias in disease prediction with LLMs.
Outcome: The proposed model alleviates the observed bias in disease prediction with LLMs.
How Can We Diagnose and Treat Bias in Large Language Models for Clinical Decision-Making? (2025.naacl-long)

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Challenge: Recent studies have shown that LLMs exhibit social biases inherited from training data.
Approach: They propose a framework for evaluation and mitigation of bias in Large Language Models applied to complex clinical cases using a dataset based on the JAMA Clinical Challenge.
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Everything you need to know about Multilingual LLMs: Towards fair, performant and reliable models for languages of the world (2023.acl-tutorials)

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Challenge: Responsible AI issues such as fairness, bias and toxicity will be discussed in this tutorial .
Approach: This tutorial will describe various aspects of scaling up language technologies to many of the world’s languages by describing the latest research in Massively Multilingual Language Models (MMLMs).
Outcome: This tutorial will cover various aspects of scaling up language technologies to many of the world's languages by describing the latest research in multilingual models.
A Systematic Survey and Critical Review on Evaluating Large Language Models: Challenges, Limitations, and Recommendations (2024.emnlp-main)

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Challenge: Large Language Models (LLMs) have gained significant attention due to their capabilities in performing diverse tasks across domains.
Approach: They review the primary challenges and limitations causing inconsistencies in evaluations . early models could generate coherent text but limited to simple tasks .
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Large Language Models Are Poor Clinical Decision-Makers: A Comprehensive Benchmark (2024.emnlp-main)

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Challenge: Existing studies focus on evaluating large language models in close-ended QA tasks, but many clinical decisions involve answering open-ended questions without pre-set options.
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Large Language Models Are Still Misled by Simple Bias Ensembles (2026.findings-acl)

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Challenge: Existing benchmarks for large language models are constrained to datasets where each sample is manually injected with only one type of bias.
Approach: They propose a multi-bias benchmark where each sample contains multiple types of biases.
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Assessing and Mitigating Medical Knowledge Drift and Conflicts in Large Language Models (2025.findings-emnlp)

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Challenge: Rapid medical concept drift can lead LLMs to provide incorrect or outdated advice.
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Outcome: The proposed benchmark evaluates how LLMs manage varied knowledge conflicts in clinical guidelines.

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