Interleaved Tool-Call Reasoning for Protein Function Understanding (2026.acl-long)
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| Challenge: | Recent advances in large language models have highlighted the effectiveness of chain-of-thought reasoning in symbolic domains such as mathematics and programming. |
| Approach: | They propose a tool-augmented protein reasoning agent that unifies problem decomposition, tool invocation, and grounded answer generation. |
| Outcome: | The proposed protein function understanding agent outperforms text-only reasoning models with an average performance improvement of 103%. |
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