Challenge: Current large language models (LLMs) are ineffective in learning domain knowledge and aligning with human preference.
Approach: They propose a benchmark LLM for Chinese medical domain that uses pre-training, supervised fine-tuning and RLHF to train LLMs.
Outcome: The proposed LLM performs better than existing LLMs in the Chinese medical domain.

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CliMedBench: A Large-Scale Chinese Benchmark for Evaluating Medical Large Language Models in Clinical Scenarios (2024.emnlp-main)

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Challenge: Chinese medical large language models (LLMs) are underperforming on this benchmark, especially where medical reasoning and factual consistency are vital.
Approach: They propose a benchmark with 14 expert-guided clinical scenarios to assess the medical ability of large language models across 7 pivot dimensions.
Outcome: The proposed benchmark has been validated in several ways.
CMB: A Comprehensive Medical Benchmark in Chinese (2024.naacl-long)

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Challenge: Large Language Models (LLMs) provide a great breakthrough in medicine, says a new study . existing studies on LLMs leverage subjective evaluation, but evaluation in medicine is professional .
Approach: They propose a localized medical benchmark in Chinese rooted in native Chinese . they propose to use traditional Chinese medicine to evaluate large-scale LLMs .
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EMPEC: A Comprehensive Benchmark for Evaluating Large Language Models Across Diverse Healthcare Professions (2025.findings-acl)

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Challenge: Recent advances in Large Language Models (LLMs) show their potential in accurately answering biomedical questions, yet current healthcare benchmarks primarily assess knowledge mastered by medical doctors, neglecting other essential professions.
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GPT-Fathom: Benchmarking Large Language Models to Decipher the Evolutionary Path towards GPT-4 and Beyond (2024.findings-naacl)

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Challenge: Existing LLM leaderboards often reference scores reported in other papers without consistent settings and prompts, which may encourage cherry-picking favored settings and for better results.
Approach: They propose an open-source and reproducible LLM evaluation suite built on top of OpenAI Evals that systematically evaluates 10+ leading LLMs and OpenAI’s legacy models on 20+ curated benchmarks across 7 capability categories.
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LlamaCare: An Instruction Fine-Tuned Large Language Model for Clinical NLP (2024.lrec-main)

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Challenge: Large language models have shown remarkable abilities in generating natural texts . applying LLMs to clinical domain still poses significant challenges .
Approach: They propose a method of instruction fine-tuning for adapting large language models to clinical domains . they generate instructions, inputs, and outputs covering a wide spectrum of clinical services .
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Large language models are few-shot clinical information extractors (2022.emnlp-main)

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Challenge: a long-running goal of clinical NLP is the extraction of important variables trapped in clinical notes.
Approach: They propose to use large language models to tackle diverse clinical extraction tasks . they propose to reannote existing CASI datasets to compare their models with clinical text.
Outcome: The proposed models outperform existing models on few-shot clinical information extraction tasks.
Leveraging Web-Crawled Data for High-Quality Fine-Tuning (2024.findings-emnlp)

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Challenge: Currently, large language models are fine-tuned using expensive human-annotated data or GPT-4 generated data.
Approach: They propose to use web-crawled data to train a language model on a smaller set of data . their results show that the model can convert web data with irregular formats into high-quality ones .
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A Zero-shot and Few-shot Study of Instruction-Finetuned Large Language Models Applied to Clinical and Biomedical Tasks (2024.lrec-main)

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Challenge: Large Language Models (LLMs) have enabled advances in the field of natural language processing . however, their application and potential are still underexplored .
Approach: They evaluate four state-of-the-art instruction-tuned Large Language Models on 13 NLP tasks in English.
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A Modular Approach for Clinical SLMs Driven by Synthetic Data with Pre-Instruction Tuning, Model Merging, and Clinical-Tasks Alignment (2025.acl-long)

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Challenge: Large language models such as GPT-4 have limited their deployment in clinical settings . a novel framework for adapting SLMs into high-performing clinical models is needed .
Approach: They propose a framework for adapting large language models into high-performing clinical models . they pre-instruct experts on relevant medical and clinical corpora and model merging .
Outcome: The proposed framework outperforms the existing model on the CLUE+ benchmark on medical entities and radiology reports.
Towards Adapting Open-Source Large Language Models for Expert-Level Clinical Note Generation (2025.findings-acl)

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Challenge: Proprietary Large Language Models (LLMs) have demonstrated promising capabilities in clinical text summarization tasks.
Approach: They propose a domain- and task-specific adaptation process for an open-source LLaMA-2 model . LLama-2 can generate high-quality clinical notes from outpatient patient-doctor dialogues .
Outcome: The proposed model can generate clinical notes comparable to those authored by physicians.

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