Challenge: Existing work has found that biomedical language models lack the knowledge needed for such tasks.
Approach: They propose to fine-tune biomedical language models on the task of predicting masked medical concepts from PubMed abstracts to improve their performance.
Outcome: The proposed strategy improves the performance of biomedical language models on the task of predicting masked medical concepts from patient case descriptions.

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Challenge: Large language models have shown remarkable abilities in generating natural texts . applying LLMs to clinical domain still poses significant challenges .
Approach: They propose a method of instruction fine-tuning for adapting large language models to clinical domains . they generate instructions, inputs, and outputs covering a wide spectrum of clinical services .
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Improving Pre-trained Language Model Sensitivity via Mask Specific losses: A case study on Biomedical NER (2024.naacl-long)

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Challenge: Fine-tuning is the prevailing practice for adapting language models (LMs) to new domains.
Approach: They propose a mask specific language model that weights the importance of domain-specific terms during fine-tuning to avoid insensitivity.
Outcome: The proposed approach outperforms advanced masking strategies such as span- and PMI-based masking.
Boosting Low-Resource Biomedical QA via Entity-Aware Masking Strategies (2021.eacl-main)

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Challenge: Biomedical question-answering (QA) provides users with high-quality information from a vast scientific literature.
Approach: They propose to use a biomedical entity-aware masking strategy to fine-tune masked language models to their domains.
Outcome: The proposed approach is an adaptation process for masked LMs, not memory or components.
Fine-Tuning Pre-trained Language Model with Weak Supervision: A Contrastive-Regularized Self-Training Approach (2021.naacl-main)

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Challenge: Fine-tuned pre-trained language models (LMs) have enormous success in many natural language processing tasks, but they still require excessive labeled data in the fine-tuning stage.
Approach: They propose a framework to enable fine-tuning pre-trained language models with weak supervision without any labeled data.
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BioReddit: Word Embeddings for User-Generated Biomedical NLP (D19-62)

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Challenge: a corpus of medical-themed posts was scrapped from Reddit to train word embeddings on downstream tasks.
Approach: They propose to train word embeddings from a corpus of medical forums from reddit scrapping posts from medical-themed subreddits.
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Boosting Transformers and Language Models for Clinical Prediction in Immunotherapy (2023.acl-industry)

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Challenge: Current machine learning approaches to predict clinical outcomes are limited to tabular data and are not applicable to clinical prediction.
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Incorporating medical knowledge in BERT for clinical relation extraction (2021.emnlp-main)

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Challenge: Pre-trained language models (PLMs) are used for diverse NLP tasks such as Information Extraction, Sentiment Analysis and Question/Answering.
Approach: They propose to add medical knowledge to pre-trained language models to facilitate clinical relation extraction using a large text corpus.
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Large Language Models Are Poor Clinical Decision-Makers: A Comprehensive Benchmark (2024.emnlp-main)

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Challenge: Existing studies focus on evaluating large language models in close-ended QA tasks, but many clinical decisions involve answering open-ended questions without pre-set options.
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Generative Biomedical Entity Linking via Knowledge Base-Guided Pre-training and Synonyms-Aware Fine-tuning (2022.naacl-main)

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Challenge: Generative methods for biomedical entity linking (EL) use synonyms knowledge from knowledge bases (KB) this is not trivial to inject into a generative method, but it is cost-effective.
Approach: They propose to inject synonyms knowledge into a generative model of biomedical EL by constructing synthetic samples with synonyms and definitions from KB and requiring the model to recover concept names.
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Can Synthetic Text Help Clinical Named Entity Recognition? A Study of Electronic Health Records in French (2023.eacl-main)

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Challenge: In sensitive domains, the sharing of corpora is restricted due to confidentiality, copyrights or trade secrets.
Approach: They use auto-regressive neural models to generate a clinical case corpus annotated with clinical entities and evaluate it for a named entity recognition task.
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