Challenge: Biomedical question-answering (QA) provides users with high-quality information from a vast scientific literature.
Approach: They propose to use a biomedical entity-aware masking strategy to fine-tune masked language models to their domains.
Outcome: The proposed approach is an adaptation process for masked LMs, not memory or components.

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Inexpensive Domain Adaptation of Pretrained Language Models: Case Studies on Biomedical NER and Covid-19 QA (2020.findings-emnlp)

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Challenge: Pretrained Language Models (PTLMs) are typically pretraining on target-domain text, which is expensive in terms of hardware, runtime and CO 2 emissions.
Approach: They propose a faster, CPU-only domainadaptation method that trains Word2Vec on target-domain text and aligns the resulting word vectors with the wordpiece vectors of a general-domain PTLM.
Outcome: The proposed method covers 60% of the BioBERT - BERT F1 delta, 5% of BioBERTS’s CO2 footprint and 2% of its cloud compute cost.
Improving Pre-trained Language Model Sensitivity via Mask Specific losses: A case study on Biomedical NER (2024.naacl-long)

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Challenge: Fine-tuning is the prevailing practice for adapting language models (LMs) to new domains.
Approach: They propose a mask specific language model that weights the importance of domain-specific terms during fine-tuning to avoid insensitivity.
Outcome: The proposed approach outperforms advanced masking strategies such as span- and PMI-based masking.
Generative Biomedical Entity Linking via Knowledge Base-Guided Pre-training and Synonyms-Aware Fine-tuning (2022.naacl-main)

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Challenge: Generative methods for biomedical entity linking (EL) use synonyms knowledge from knowledge bases (KB) this is not trivial to inject into a generative method, but it is cost-effective.
Approach: They propose to inject synonyms knowledge into a generative model of biomedical EL by constructing synthetic samples with synonyms and definitions from KB and requiring the model to recover concept names.
Outcome: The proposed method achieves state-of-the-art results on several biomedical EL tasks without candidate selection.
Self-Supervised Intermediate Fine-Tuning of Biomedical Language Models for Interpreting Patient Case Descriptions (2022.coling-1)

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Challenge: Existing work has found that biomedical language models lack the knowledge needed for such tasks.
Approach: They propose to fine-tune biomedical language models on the task of predicting masked medical concepts from PubMed abstracts to improve their performance.
Outcome: The proposed strategy improves the performance of biomedical language models on the task of predicting masked medical concepts from patient case descriptions.
Guiding Large Language Models for Biomedical Entity Linking via Restrictive and Contrastive Decoding (2025.findings-emnlp)

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Challenge: Existing attempts to apply large language models to BioEL have revealed difficulties .
Approach: They propose a framework that enables large language models to adapt well to BioEL . they employ restrictive decoding to ensure the generation of valid entities .
Outcome: Extensive experiments show that the framework outperforms existing LLMs.
QA Analysis in Medical and Legal Domains: A Survey of Data Augmentation in Low-Resource Settings (2025.acl-srw)

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Challenge: Large Language Models (LLMs) have revolutionized natural language processing, but their success remains limited to high-resource domains.
Approach: They analyze the coverage and representativeness of specialized-domain QA datasets against large-scale reference datasets.
Outcome: The proposed methods and evaluations highlight the challenges faced by LLMs in low-resource domains.
BioMedBERT: A Pre-trained Biomedical Language Model for QA and IR (2020.coling-main)

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Challenge: SARS-CoV-2 pandemic highlighted importance of moving quickly with biomedical research.
Approach: They propose a textual data mining tool that supports literature search to accelerate the work of researchers in the biomedical domain.
Outcome: The proposed model achieves state-of-the-art results on the QA fine-tuning task on BioASQ 5b, 6b and 7b datasets.
Named Entity Recognition Under Domain Shift via Metric Learning for Life Sciences (2024.naacl-long)

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Challenge: Existing models for named entity recognition fail in scientific domains such as biomedicine and chemistry.
Approach: They propose a model to transfer knowledge from the biomedical domain to the target domain . they use pseudo labeling and contrastive learning to enhance discrimination .
Outcome: The proposed model outperforms baseline models by up to 5% . the proposed model is based on a biomedical domain model and a chemical domain model .
Medical Adaptation of Large Language and Vision-Language Models: Are We Making Progress? (2024.emnlp-main)

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Challenge: Several studies claim that domain-adaptive pretraining improves performance on downstream medical tasks.
Approach: They compare medical LLMs and VLMs against their corresponding base models . they find that medical Lms outperform their base models in 12.1% of cases .
Outcome: The proposed models outperform their base models on medical questions and tasks in 12.1% of cases and reach a tie in 49.8% of cases.
Hardness-guided domain adaptation to recognise biomedical named entities under low-resource scenarios (2022.emnlp-main)

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Challenge: Named Entity Recognition (NER) tasks require a large amount of training data and domains are often scarcely labeled.
Approach: They propose a hardness-guided domain adaptation framework for bioNER tasks that leverages domain hardness information to improve the adaptability of the learnt model in low-resource scenarios.
Outcome: The proposed model outperforms the state-of-the-art MetaNER model on biomedical datasets.

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