A Survey of Large Language Models for Text-Guided Molecular Discovery: From Molecule Generation to Optimization (2026.acl-long)
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| Challenge: | Large language models (LLMs) are introducing a paradigm shift in molecular discovery by enabling text-guided interaction with chemical spaces through natural language and symbolic notations. |
| Approach: | They analyze the current LLM learning paradigms to tackle four critical evaluation dimensions that have emerged as critical dimensions in recent studies. |
| Outcome: | The proposed models are able to interact with chemical spaces through natural language and symbolic notations, and have emerging extensions to incorporate multi-modal inputs. |
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