Papers by Pengan Chen

4 papers
How Well Do LLMs Handle Cantonese? Benchmarking Cantonese Capabilities of Large Language Models (2025.findings-naacl)

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Challenge: Cantonese has scant representation in NLP research, especially compared to other languages from similarly developed regions.
Approach: They propose to evaluate Cantonese LLM performance in factual generation, mathematical logic, complex reasoning, and general knowledge in Cantonesian.
Outcome: The proposed models will evaluate Cantonese's performance in factual generation, mathematical logic, complex reasoning, and general knowledge in Cantone.
Large Language Models in Bioinformatics: A Survey (2025.findings-acl)

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Challenge: Large Language Models (LLMs) are revolutionizing bioinformatics, enabling advanced analysis of DNA, RNA, proteins, and single-cell data.
Approach: They examine the evolution of Large Language Models (LLMs) in bioinformatics and precision medicine by focusing on genomic sequence modeling, RNA structure prediction, protein function inference, and single-cell transcriptomics.
Outcome: The proposed models are capable of predicting RNA structure and function and predicting single-cell transcriptomics.
Developing and Utilizing a Large-Scale Cantonese Dataset for Multi-Tasking in Large Language Models (2025.findings-emnlp)

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Challenge: Cantonese is considered a low-resource language due to the dominance of Mandarin . rich colloquial vocabulary of Cantone, English loanwords, and code-switching characteristics add to the complexity of corpus collection and processing.
Approach: We collect Cantonese texts from open source corpora, Hong Kong-specific forums, Wikipedia . we refine the model through supervised fine-tuning on curated Cantonesian tasks .
Outcome: The model achieves state-of-the-art (SOTA) performance on four Cantonese benchmarks.
LM2Protein: A Structure-to-Token Protein Large Language Model (2025.findings-emnlp)

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Challenge: RNA-binding proteins are critical for various molecular functions, relying on their precise tertiary structures.
Approach: They propose a method to integrate protein 3D structural data within a sequence processing framework.
Outcome: The proposed method achieves high sequence recovery in inverse folding and protein-conditioned RNA design.

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