Challenge: Large language models (LLMs) have great potential to facilitate explainable diagnosis, but their effectiveness is often constrained by insufficient diagnostic expertise.
Approach: They propose a unified LLM-based framework for faithful and explainable diagnosis that builds a high-quality diagnostic knowledge base through a record-driven explanation learning paradigm.
Outcome: The proposed framework outperforms baselines on the DiReCT and JAMA benchmarks and improves the explanation completeness metric from 64.5% to 76.9% over the best existing methods.

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Challenge: Large language models (LLMs) adopt autoregressive architecture, predicting the next word token based on the preceding context.
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A Diagnostic Study of Explainability Techniques for Text Classification (2020.emnlp-main)

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Challenge: Existing explainability techniques that can be produced post-hoc with already trained models are lacking a definitive guide on how to choose one given a particular task and model architecture.
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Knowledge-Augmented Multimodal Clinical Rationale Generation for Disease Diagnosis with Small Language Models (2025.acl-long)

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Challenge: Existing models struggle to balance predictive accuracy with human-understandable rationales.
Approach: They propose to enhance LLMs by leveraging rationale distillation and domain knowledge injection for trustworthy multimodal rationale generation.
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CoD, Towards an Interpretable Medical Agent using Chain of Diagnosis (2025.findings-acl)

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Challenge: Existing large language models (LLMs) are proving to be effective in medical automatic diagnosis, but their interpretability remains unaddressed.
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DiagnosisArena: Benchmarking Diagnostic Reasoning for Large Language Models (2026.findings-acl)

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Challenge: Existing medical benchmarks for diagnostic reasoning are limited in their ability to perform complex tasks.
Approach: They propose to benchmark diagnostic capabilities of large language models to assess their accuracy and generalization bottlenecks.
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Faithful Serum: Mitigating the Faithfulness Gap in Textual Explanations of LLM Decisions via Attribution Guidance (2026.acl-long)

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Challenge: Prior work has focused on generating convincing rationales that appear to be subjectively faithful, but it remains unclear whether these explanations are epistemic faithful.
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No Black Boxes: Interpretable and Interactable Predictive Healthcare with Knowledge-Enhanced Agentic Causal Discovery (2025.findings-emnlp)

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Challenge: Deep learning models lacking interpretability and interactivity, authors say . lack of interactive mechanisms prevents clinicians from incorporating their own knowledge into decision-making process.
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ExPerT: Effective and Explainable Evaluation of Personalized Long-Form Text Generation (2025.findings-acl)

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Challenge: Evaluating personalized text generated by large language models is challenging, as only the LLM user, i.e. prompt author, can reliably assess the output.
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CoAD: Automatic Diagnosis through Symptom and Disease Collaborative Generation (2023.acl-long)

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Challenge: Automated diagnosis (AD) is a critical application of AI in healthcare . despite its simplicity and superior performance, a decline in disease diagnosis accuracy is observed .
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medIKAL: Integrating Knowledge Graphs as Assistants of LLMs for Enhanced Clinical Diagnosis on EMRs (2025.coling-main)

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Challenge: Electronic Medical Records (EMRs) are the digitized record of a patient's medical and health information and are integral to modern healthcare.
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