Challenge: a 1999 report found that at least forty thousand deaths are a result of preventable medical errors.
Approach: They test pre-trained language models to characterize their error generation and reliability in medical assessment ability.
Outcome: The results show that pre-trained models can generate errors and perform better than human models.

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Large Language Models Are Poor Clinical Decision-Makers: A Comprehensive Benchmark (2024.emnlp-main)

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Challenge: Existing studies focus on evaluating large language models in close-ended QA tasks, but many clinical decisions involve answering open-ended questions without pre-set options.
Approach: They construct a benchmark to better understand large language models in the clinic . they use existing datasets to evaluate LLMs in clinical situations .
Outcome: The proposed model outperforms human experts in multiple medical tasks.
A Systematic Survey and Critical Review on Evaluating Large Language Models: Challenges, Limitations, and Recommendations (2024.emnlp-main)

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Challenge: Large Language Models (LLMs) have gained significant attention due to their capabilities in performing diverse tasks across domains.
Approach: They review the primary challenges and limitations causing inconsistencies in evaluations . early models could generate coherent text but limited to simple tasks .
Outcome: The proposed evaluations are reproducible, reliable, and robust.
Exploring the Reliability of Large Language Models as Customized Evaluators for Diverse NLP Tasks (2025.coling-main)

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Challenge: Existing work uses large language models (LLMs) to evaluate natural language process tasks, but there are shortcomings in current LLMs.
Approach: They examine the alignment between LLM evaluators and human annotators by comparing conventional and alignment tasks with different evaluation criteria.
Outcome: The proposed models excel in general criteria, such as fluency, but face challenges with complex criteria, including numerical reasoning.
Medical Adaptation of Large Language and Vision-Language Models: Are We Making Progress? (2024.emnlp-main)

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Challenge: Several studies claim that domain-adaptive pretraining improves performance on downstream medical tasks.
Approach: They compare medical LLMs and VLMs against their corresponding base models . they find that medical Lms outperform their base models in 12.1% of cases .
Outcome: The proposed models outperform their base models on medical questions and tasks in 12.1% of cases and reach a tie in 49.8% of cases.
Can LLMs Reason Like Doctors? Exploring the Limits of Large Language Models in Complex Medical Reasoning (2026.findings-eacl)

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Challenge: Large language models (LLMs) have shown remarkable progress in reasoning across multiple domains, but it remains unclear whether their abilities reflect genuine reasoning or sophisticated pattern matching.
Approach: They conduct one of the largest evaluations to date, assessing 77 LLMs . they select three medical question answering (QA) benchmarks targeting reasoning processes .
Outcome: The results highlight the need to improve specific reasoning strategies to better reflect medical decision-making.
Are LLMs reliable? An exploration of the reliability of large language models in clinical note generation (2025.acl-industry)

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Challenge: Clinical note generation (CNG) tools are being developed to address extended working hours and healthcare provider fatigue.
Approach: They evaluate the reliability of 12 open-weight and proprietary LLMs from Anthropic, Meta, Mistral, and OpenAI in CNG in terms of their ability to generate notes that are string equivalent (consistency rate), have the same meaning (semantic consistency) and are correct (symbol similarity)
Outcome: The results show that the LLMs generated notes that are string equivalent (consistency rate), have the same meaning (semantic consistency) and are correct (symbol similarity) overall, Meta’s Llama 70B was the most reliable, followed by Mistral’s Small model.
LLMEval-Med: A Real-world Clinical Benchmark for Medical LLMs with Physician Validation (2025.findings-emnlp)

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Challenge: Current medical benchmarks have limitations in question design, data sources and evaluation methods.
Approach: They propose a new benchmark covering five core medical areas . it includes 2,996 questions created from real-world electronic health records .
Outcome: The proposed model covers five core medical areas and includes 2,996 questions created from real-world electronic health records and expert-designed clinical scenarios.
Challenging Large Language Models with New Tasks: A Study on their Adaptability and Robustness (2024.findings-acl)

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Challenge: Existing evaluation approaches for large language models (LLMs) rely on existing tasks and benchmarks, raising concerns about test set contamination and the genuine comprehension abilities of LLMs.
Approach: They propose to evaluate LLMs by designing new tasks, automatically generating evaluation datasets for the tasks, and conducting detailed error analyses to scrutinize LLM's adaptability to new tasks.
Outcome: The proposed method examines LLMs’ adaptability to new tasks, their sensitivity to prompt variations, and their error tendencies.
From Scores to Steps: Diagnosing and Improving LLM Performance in Evidence-Based Medical Calculations (2025.emnlp-main)

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Challenge: Existing benchmarks assess only the final answer with a wide numerical tolerance, overlooking systematic reasoning failures and potentially causing serious clinical misjudgments.
Approach: They propose a new step-by-step evaluation pipeline that assesses formula selection, entity extraction, and arithmetic computation.
Outcome: The proposed method improves the accuracy of large language models on medical benchmarks from 16.35% to 53.19%.
Are Large Language Model-based Evaluators the Solution to Scaling Up Multilingual Evaluation? (2024.findings-eacl)

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Challenge: Large Language Models (LLMs) excel in various tasks, but their evaluation, especially in languages beyond the top 20, remains inadequate due to existing benchmarks and metrics limitations.
Approach: They propose to use Large Language Models as evaluators to rank or score other models’ outputs by calibrating them against 20K human judgments across three text-generation tasks, five metrics, and eight languages.
Outcome: The proposed evaluation methods can be used to improve multilingual evaluation by calibrating them against 20K human judgments across three text-generation tasks, five metrics, and eight languages.

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