Challenge: Existing models generate erroneous information and evaluations fail to assess factual correctness of models.
Approach: They propose to use MoleculeQA to evaluate molecular factual correctness in large language models by organizing molecules into a taxonomy and building QA pairs through human and LLM efforts.
Outcome: The proposed model improves the factual correctness of generated information and enables the development of new models.

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PeerQA: A Scientific Question Answering Dataset from Peer Reviews (2025.naacl-long)

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Challenge: a dataset of 579 QA pairs from 208 scientific articles contains answers that reviewers raised while thoroughly examining the scientific article.
Approach: They propose a dataset that contains questions that reviewers raised while thoroughly examining the scientific article.
Outcome: The proposed dataset contains 579 QA pairs from 208 academic articles . the results show that decontextualization approaches improve retrieval performance .
A Survey of Large Language Models for Text-Guided Molecular Discovery: From Molecule Generation to Optimization (2026.acl-long)

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Challenge: Large language models (LLMs) are introducing a paradigm shift in molecular discovery by enabling text-guided interaction with chemical spaces through natural language and symbolic notations.
Approach: They analyze the current LLM learning paradigms to tackle four critical evaluation dimensions that have emerged as critical dimensions in recent studies.
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Chinese SimpleQA: A Chinese Factuality Evaluation for Large Language Models (2025.acl-long)

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Challenge: Current frontier models sometimes generate false outputs or answers that are not substantiated by evidence.
Approach: They propose Chinese SimpleQA, a Chinese benchmark to evaluate LLMs' factuality . they focus on Chinese language over 6 major topics with 99 diverse subtopics .
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SciDQA: A Deep Reading Comprehension Dataset over Scientific Papers (2024.emnlp-main)

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Challenge: SciDQA is a dataset for question-answering that challenges language models to deeply understand scientific articles.
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Outcome: The SciDQA dataset is based on 2,937 QA pairs and decontextualizes the content, tracks the source document across different versions, and incorporates a bibliography for multi-document question-answering.
GenomeQA: Benchmarking General Large Language Models for Genome Sequence Understanding (2026.acl-long)

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Challenge: Existing benchmarks focus on specialized DNA models trained for sequence prediction or evaluate biological knowledge using text-only questions.
Approach: They propose a benchmark to evaluate general-purpose LLMs on sequence-based genome inference tasks.
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Factuality of Large Language Models: A Survey (2024.emnlp-main)

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Challenge: Large language models (LLMs) are factually incorrect, which limits their applicability in real-world scenarios.
Approach: They analyze existing work to identify major challenges and their associated causes . they propose to evaluate LLMs using a variety of measures to mitigate factual errors .
Outcome: The proposed methods are based on a variety of datasets and proposed strategies to mitigate factual errors.
Chinese SafetyQA: A Safety Short-form Factuality Benchmark for Large Language Models (2025.acl-long)

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Challenge: Large language models have created significant safety concerns . factuality ability is crucial in determining whether they can be deployed and applied safely and compliantly within specific regions.
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NOAHQA: Numerical Reasoning with Interpretable Graph Question Answering Dataset (2021.findings-emnlp)

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Challenge: Existing question answering datasets lack numerical reasoning and reasoning processes . current research on numerical reasoning focuses on simple calculations .
Approach: They propose a conversational and bilingual question answering dataset with numerical reasoning with compound mathematical expressions.
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Less for More: Enhanced Feedback-aligned Mixed LLMs for Molecule Caption Generation and Fine-Grained NLI Evaluation (2025.acl-long)

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Challenge: Recent trends have led to the use of multimodal models to learn molecular and linguistic representations, either in separate but coordinated spaces or in a common space.
Approach: They propose a novel atomic-level evaluation method leveraging off-the-shelf Natural Language Inference (NLI) models for use in the unseen chemical domain.
Outcome: The proposed method surpasses state-of-the-art models in the unseen chemical domain while relying on a granularity-based evaluation method.
Exploring the Factual Consistency in Dialogue Comprehension of Large Language Models (2024.naacl-long)

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Challenge: LLMs generate responses following user's instructions, which requires high dialogue comprehension ability.
Approach: They propose to evaluate LLMs' dialogue comprehension ability using a dialogue summarization task to derive factual questions from the generated summaries and use them as a more flexible measurement of dialogue comprehension.
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