Challenge: Pre-trained language models (PLMs) are the leading paradigm in document-level relation extraction.
Approach: They propose a cascade framework that leverages the complementary strengths of PLMs and LLMs through a detect-then-rethink paradigm.
Outcome: The proposed framework improves on BioRED and CDR datasets and improves existing models.

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GLiM: Integrating Graph Transformer and LLM for Document-Level Biomedical Relation Extraction with Incomplete Labeling (2025.findings-acl)

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Challenge: Document-level relation extraction (DocRE) solves problems of document quality . number of entities and entity-pair relations increases, causing incomplete annotations .
Approach: a framework that reduces the problem space using a graph-enhanced Transformer-based model is proposed . GLiM leverages large language models for reasoning to reduce the problem-space .
Outcome: GLiM boosts average recall and F1 scores on biomedical datasets . compared with existing models, GLim outperforms existing models on biomedicine benchmarks compared to existing models .
Document-level Biomedical Relation Extraction Based on Multi-Dimensional Fusion Information and Multi-Granularity Logical Reasoning (2022.coling-1)

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Challenge: Existing models with reasoning are single-granularity based on one element information, ignoring complementary fact of different granularities.
Approach: They propose a document-level biomedical relation extraction model called FILR . it uses multi-dimensional information fusion and multi-granularity logic to obtain rich inferences .
Outcome: The proposed model extracts all relation facts from biomedical documents . it is based on multi-dimensional information fusion and multi-granularity logic reasoning . the proposed model achieves state-of-the-art performance on two widely used biomedically corpora .
Modular Self-Supervision for Document-Level Relation Extraction (2021.emnlp-main)

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Challenge: Prior work on information extraction tends to focus on binary relations within sentences . practical applications often require extracting complex relations across large text spans .
Approach: They propose to decompose document-level relation extraction into relation detection and argument resolution, taking inspiration from Davidsonian semantics.
Outcome: The proposed method outperforms state-of-the-art methods in biomedical machine reading for precision oncology by 20 absolute F1 points.
Reasoning with Latent Structure Refinement for Document-Level Relation Extraction (2020.acl-main)

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Challenge: Existing methods for document-level relation extraction capture non-local interactions but are not able to capture rich non-linguistic interactions.
Approach: They propose a document-level relation extraction model that empowers relational reasoning across sentences by automatically inducing the latent document- level graph.
Outcome: The proposed model achieves an F1 score of 59.05 on a large-scale document-level dataset (DocRED), significantly improving over the previous results.
Federated Document-Level Biomedical Relation Extraction with Localized Context Contrast (2024.lrec-main)

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Challenge: Existing studies on relation extraction focus on document-level training without sharing raw medical texts.
Approach: They propose a federated framework for relation extraction that enables collaborative training without sharing raw medical texts.
Outcome: The proposed framework extends document-level relation extraction to a federated environment.
TTM-RE: Memory-Augmented Document-Level Relation Extraction (2024.acl-long)

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Challenge: Existing methods for document-level relation extraction are ineffective in exploiting the full potential of large amounts of training data with varied noise levels.
Approach: They propose a novel approach that integrates a trainable memory module with a noisy-robust loss function that accounts for the positive-unlabeled setting to unlock the full potential of large-scale noisy training data.
Outcome: The proposed model outperforms existing methods on a ReDocRED benchmark dataset with an absolute F1 score improvement of over 3%.
Double Graph Based Reasoning for Document-level Relation Extraction (2020.emnlp-main)

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Challenge: Existing methods for document-level relation extraction fail to recognize relations between entities across sentences.
Approach: They propose a method to recognize relations for long paragraphs by a Graph Aggregation-and-Inference Network (GAIN) they propose to use a heterogeneous mention-level graph and an entity-level EG graph to analyze the relationships.
Outcome: The proposed method achieves a significant performance improvement (2.85 on F1) over the previous state-of-the-art.
SAIS: Supervising and Augmenting Intermediate Steps for Document-Level Relation Extraction (2022.naacl-main)

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Challenge: Existing methods for relation extraction only implicitly learn to model relevant contexts and entity types while being trained for RE.
Approach: They propose to explicitly teach the model to capture relevant contexts and entity types by supervising and augmenting intermediate steps (SAIS) for RE.
Outcome: The proposed method outperforms the runner-up method on three benchmarks by 5.04% . textual contexts and entity types are the major information sources that lead to the success of previous approaches.
SRF: Enhancing Document-Level Relation Extraction with a Novel Secondary Reasoning Framework (2024.emnlp-main)

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Challenge: Existing methods for document-level relation extraction ignore bidirectional mention interaction when generating relational features for entity pairs.
Approach: They propose a document-level relation extraction model that incorporates bidirectional mention fusion and a simple yet effective evidence extraction module for relation prediction.
Outcome: The proposed model achieves SOTA performance and the proposed method is effective and general when integrated into existing models.
Semi-automatic Data Enhancement for Document-Level Relation Extraction with Distant Supervision from Large Language Models (2023.emnlp-main)

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Challenge: Document-level Relation Extraction (DocRE) is a task that aims to extract relations from a long context.
Approach: They propose an automated annotation method that integrates an LLM and a natural language inference module to generate relation triples.
Outcome: The proposed method can extract relations from document-level relation datasets with minimal human effort.

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