Challenge: Existing methods for crystal generation are limited to zero-shot scenarios and are unable to benefit from few-shot situations.
Approach: They propose a model designed for few-shot crystal generation that exploits in-context learning by capturing structure-property relationships from limited data.
Outcome: The proposed model reduces complexity of modeling crystal symmetry in LLMs and exploits ICL by capturing structure-property relationships from limited data.

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OpenICL: An Open-Source Framework for In-context Learning (2023.acl-demo)

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Challenge: In-context Learning (ICL) is a new paradigm for large language model evaluation.
Approach: They propose an open-source toolkit for ICL and LLM evaluation.
Outcome: The proposed framework is highly flexible and flexible and can be easily combined with other tools to suit users' needs.
More is not always better? Enhancing Many-Shot In-Context Learning with Differentiated and Reweighting Objectives (2025.acl-long)

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Challenge: Large language models excel at few-shot in-context learning but performance plateaus as ICL demonstrations increase from a few to many.
Approach: They propose a novel optimization method that optimizes the negative log-likelihood objective and reweights the model to achieve many-shot performance.
Outcome: The proposed method achieves significant performance improvements across a large-scale dataset.
ParaICL: Towards Parallel In-Context Learning (2025.naacl-long)

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Challenge: Existing methods to improve ICL performance are limited by the length of the input context.
Approach: They propose a method that utilizes all demonstration examples without exceeding the manageable context length.
Outcome: The proposed method can be scaled up to integrate with existing methods.
Large Language Models for Controllable Multi-property Multi-objective Molecule Optimization (2025.findings-emnlp)

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Challenge: Existing methods for molecule optimization fail to capture property-specific objectives . a series of instruction-tuned LLMs can perform targeted property-specific optimization .
Approach: They propose a set of instruction-tuned LLMs that can perform targeted property-specific optimization.
Outcome: a new instruction-tuned LLM can perform targeted property-specific optimization.
Enhancing Low-Resource LLMs Classification with PEFT and Synthetic Data (2024.lrec-main)

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Challenge: Large Language Models (LLMs) operating in 0-shot or few-shot settings achieve competitive results in Text Classification tasks.
Approach: They propose to make Large Language Models (LLMs) operating in 0-shot or few-shot settings as efficient as 0- shot text classifiers by leveraging a small number of samples.
Outcome: The proposed model is able to perform better on multiple datasets than existing models on 0-shot or few-shot settings.
C-ICL: Contrastive In-context Learning for Information Extraction (2024.findings-emnlp)

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Challenge: Existing methods for in-context learning with large language models focus on using correct or negative examples, ignoring the potential value of incorrect or negative samples.
Approach: They propose a few-shot technique that leverages both correct and incorrect sample constructions to create in-context learning demonstrations.
Outcome: The proposed technique outperforms previous few-shot in-context learning methods on a broad spectrum of related tasks.
GAMIC: Graph-Aligned Molecular In-context Learning for Molecule Analysis via LLMs (2025.findings-emnlp)

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Challenge: Current methods for retrieving large language models rely on molecule feature similarity, such as Morgan fingerprints, which do not adequately capture the global molecular and atom-binding relationships.
Approach: They propose a self-supervised learning technique that embeds demonstration examples into the input prompt.
Outcome: The proposed technique outperforms simple Morgan-based retrieval methods across tasks by up to 45%.
Beyond In-Context Learning: Aligning Long-form Generation of Large Language Models via Task-Inherent Attribute Guidelines (2025.findings-acl)

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Challenge: In-context learning is an important but not fully understood ability of pre-trained large language models.
Approach: They propose a tool that generates two streams of guidelines capturing task language and format distributions and prompts them to define them by prompting.
Outcome: The proposed model improves both strong open- and closed-source LLMs by over 5% in both zero- and few-shot settings.
Training Text-to-Molecule Models with Context-Aware Tokenization (2025.findings-emnlp)

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Challenge: Text-to-molecule models have shown great potential across chemical applications . however, they rely on atom-level tokenizations, which limiting the ability of models to capture global structural context within molecules.
Approach: They propose a text-to-molecule model that uses substructure-level tokenizations to model global connectivity.
Outcome: The proposed model outperforms state-of-the-art models using only 2% of training tokens.
Focused Large Language Models are Stable Many-Shot Learners (2024.emnlp-main)

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Challenge: In-Context Learning (ICL) enables large language models to achieve rapid task adaptation by learning from demonstrations.
Approach: They propose a training-free method that disperses model attention from the query . they propose 'focus' search strategy that uses model perplexity to ensure sufficient attention .
Outcome: The proposed method achieves an average performance improvement of 5.2% over vanilla ICL and scales well with many-shot demonstrations.

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