Challenge: Existing approaches to biomedical entity linking suffer from multiple types of errors due to the rarity of many biomedically relevant entities in real-world scenarios.
Approach: They propose a latent feature generation framework to generate latent semantic features for unseen entities to capture fine-grained coherence information of unseened entities.
Outcome: The proposed framework is superior to existing models on two benchmark datasets.

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Generative Biomedical Entity Linking via Knowledge Base-Guided Pre-training and Synonyms-Aware Fine-tuning (2022.naacl-main)

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Challenge: Generative methods for biomedical entity linking (EL) use synonyms knowledge from knowledge bases (KB) this is not trivial to inject into a generative method, but it is cost-effective.
Approach: They propose to inject synonyms knowledge into a generative model of biomedical EL by constructing synthetic samples with synonyms and definitions from KB and requiring the model to recover concept names.
Outcome: The proposed method achieves state-of-the-art results on several biomedical EL tasks without candidate selection.
Improving Entity Linking by Modeling Latent Relations between Mentions (P18-1)

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Challenge: Entity linking systems often exploit relations between textual mentions to decide if the linking decisions are compatible.
Approach: They treat relations as latent variables while optimizing the neural entity-linking model without supervision.
Outcome: The proposed model outperforms its relation-agnostic version and significantly outperformed its relational version.
BioEL: A Comprehensive Python Package for Biomedical Entity Linking (2025.findings-naacl)

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Challenge: Entity Linking in biomedical literature is a critical task that enhances the extraction and integration of information from diverse scientific literature.
Approach: They propose a Python package that allows for better Entity Linking in biomedical literature . the package includes four components: Ontology Object, Dataset Object and Evaluation Framework .
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Guiding Large Language Models for Biomedical Entity Linking via Restrictive and Contrastive Decoding (2025.findings-emnlp)

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Challenge: Existing attempts to apply large language models to BioEL have revealed difficulties .
Approach: They propose a framework that enables large language models to adapt well to BioEL . they employ restrictive decoding to ensure the generation of valid entities .
Outcome: Extensive experiments show that the framework outperforms existing LLMs.
Clustering-based Inference for Biomedical Entity Linking (2021.naacl-main)

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Challenge: Existing approaches to linking entities ignore relationships between entities in biomedical knowledge bases.
Approach: They propose a model which can link mentions of unseen entities using learned representations of entities.
Outcome: The proposed model improves on the largest publicly available biomedical dataset by 3.0 points of accuracy and 2.3 points of reliability.
A Comprehensive Evaluation of Biomedical Entity Linking Models (2023.emnlp-main)

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Challenge: Current methods struggle to correctly link genes and proteins and often have difficulty incorporating context into linking decisions.
Approach: They evaluate nine recent state-of-the-art biomedical entity linking models under a unified framework.
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Learning from Negative Samples in Biomedical Generative Entity Linking (2025.findings-acl)

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Challenge: Generative models are usually trained only with positive samples and do not explicitly learn from hard negative samples, which are entities that look similar but have different meanings.
Approach: They propose a framework that trains generative BioEL models using negative samples to learn from hard negative samples.
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Knowledge-Rich Self-Supervision for Biomedical Entity Linking (2022.findings-emnlp)

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Challenge: Entity linking is challenging in high-value domains with myriad entities . standard classification approaches suffer from the annotation bottleneck .
Approach: They propose a self-supervised approach to learn domain knowledge for biomedical entity linking . it generates self-reported mention examples on unlabeled text and trains contextual encoder .
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BERT might be Overkill: A Tiny but Effective Biomedical Entity Linker based on Residual Convolutional Neural Networks (2021.findings-emnlp)

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Challenge: Biomedical entity linking is a task of linking entities in biomedical documents to referent entities in a knowledge base.
Approach: They propose an efficient convolutional neural network with residual connections for biomedical entity linking.
Outcome: The proposed model achieves comparable or even better linking accuracy on five public datasets while having about 60 times fewer parameters.
LLM as Entity Disambiguator for Biomedical Entity-Linking (2025.acl-short)

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Challenge: Entity linking involves normalizing a mention in medical text to a unique identifier in a knowledge base, such as UMLS or MeSH.
Approach: They propose to use a large language model as an entity disambiguator to enhance the accuracy of alias-matching entity linking methods.
Outcome: The proposed method surpasses existing methods on biomedical datasets by up to 16 points in accuracy.

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