A Comprehensive Evaluation of Biomedical Entity-centric Search (2022.emnlp-industry)

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Challenge: a novel algorithm for information retrieval from biomedical abstracts is used to identify entities.
Approach: They perform a fine-grained evaluation of a BERT-based biomedical search engine . they use manually annotated PubMed abstracts and off-she-shelf Elasticsearch .
Outcome: The proposed system performs better for disease and gene search queries than other systems.

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A Domain-Specific Curated Benchmark for Entity and Document-Level Relation Extraction (2026.findings-eacl)

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Challenge: Existing biomedical IE benchmarks are narrow in scope and rely heavily on distantly supervised annotations.
Approach: They propose a benchmark for Information Extraction (IE) that annotates entities, concept-level links, and relations manually from PubMed abstracts.
Outcome: The GutBrainIE benchmark is based on more than 1,600 PubMed abstracts, manually annotated by biomedical and terminological experts with fine-grained entities, concept-level links, and relations.
BERT might be Overkill: A Tiny but Effective Biomedical Entity Linker based on Residual Convolutional Neural Networks (2021.findings-emnlp)

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Challenge: Biomedical entity linking is a task of linking entities in biomedical documents to referent entities in a knowledge base.
Approach: They propose an efficient convolutional neural network with residual connections for biomedical entity linking.
Outcome: The proposed model achieves comparable or even better linking accuracy on five public datasets while having about 60 times fewer parameters.
Entity Decomposition with Filtering: A Zero-Shot Clinical Named Entity Recognition Framework (2025.naacl-long)

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Challenge: Recent studies have demonstrated that large language models (LLMs) can perform in named entity recognition tasks.
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Zero-shot Medical Entity Retrieval without Annotation: Learning From Rich Knowledge Graph Semantics (2021.findings-acl)

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Challenge: Current approaches to medical entity retrieval generalize poorly to unseen sub-specialties . zero-shot retrieval is challenging due to the high degree of ambiguity and variability in medical corpora .
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A Comprehensive Evaluation of Biomedical Entity Linking Models (2023.emnlp-main)

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Challenge: Current methods struggle to correctly link genes and proteins and often have difficulty incorporating context into linking decisions.
Approach: They evaluate nine recent state-of-the-art biomedical entity linking models under a unified framework.
Outcome: The proposed models are compared along axes of accuracy, speed, ease of use, generalization, adaptability and adaptability to new ontologies and datasets.
Named Entity Recognition for Chinese biomedical patents (2020.coling-main)

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Challenge: Existing attempts to address NER for Chinese biomedical texts have been limited due to the amount of Chinese biomedicine discoveries being patented.
Approach: They train and evaluate Chinese biomedical patents NER models based on BERT . their model is optimized for Chinese bio-patent data and scored an F1 .
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OpenBioNER: Lightweight Open-Domain Biomedical Named Entity Recognition Through Entity Type Description (2025.findings-naacl)

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Challenge: Biomedical Named Entity Recognition (BioNER) is a computationally expensive and limited tool . specialized 7B NER LLMs and GPT-4o can't match textual spans with entity types .
Approach: They propose a lightweight BERT-based cross-encoder architecture that can identify any biomedical entity using only its description.
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Fine-grained Information Extraction from Biomedical Literature based on Knowledge-enriched Abstract Meaning Representation (2021.acl-long)

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Challenge: Compared with general natural language texts, sentences from scientific papers usually possess wider contexts between knowledge elements.
Approach: They propose a novel biomedical Information Extraction model to extract scientific entities and events from English research papers using Abstract Meaning Representation (AMR) they construct a sentence-level knowledge graph from an external knowledge base and encode it to improve the model's understanding of complex scientific concepts.
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Generative Biomedical Entity Linking via Knowledge Base-Guided Pre-training and Synonyms-Aware Fine-tuning (2022.naacl-main)

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Challenge: Generative methods for biomedical entity linking (EL) use synonyms knowledge from knowledge bases (KB) this is not trivial to inject into a generative method, but it is cost-effective.
Approach: They propose to inject synonyms knowledge into a generative model of biomedical EL by constructing synthetic samples with synonyms and definitions from KB and requiring the model to recover concept names.
Outcome: The proposed method achieves state-of-the-art results on several biomedical EL tasks without candidate selection.
Named Entity Recognition for Entity Linking: What Works and What’s Next (2021.findings-emnlp)

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Challenge: Entity Linking (EL) systems have achieved impressive results on standard benchmarks thanks to the contextualized representations provided by recent pretrained language models.
Approach: They propose to exploit Named Entity Recognition (NER) to narrow the gap between EL systems trained on high and low amounts of labeled data.
Outcome: The proposed model can be exploited to narrow the gap between EL systems trained on high and low amounts of labeled data.

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