Challenge: Current approaches to medical entity retrieval generalize poorly to unseen sub-specialties . zero-shot retrieval is challenging due to the high degree of ambiguity and variability in medical corpora .
Approach: They propose a set of learning tasks designed to train efficient zero-shot entity retrieval models.
Outcome: The proposed architecture outperforms common zero-shot benchmarks with 7% to 30% higher recall across multiple major medical ontologies.

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Challenge: Effective zero-shot dense retrieval in the medical domain remains difficult due to the scarcity of relevance-labeled data.
Approach: They propose a framework that leverages large language models to generate hypothetical documents . they also propose 'CMIRB' to provide a rigorous evaluation suite .
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Entity Decomposition with Filtering: A Zero-Shot Clinical Named Entity Recognition Framework (2025.naacl-long)

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Challenge: Recent studies have demonstrated that large language models (LLMs) can perform in named entity recognition tasks.
Approach: They propose a framework for clinical named entity recognition that decomposes the entity recognition task into several retrievals of sub-types and then filters them.
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Scalable Zero-shot Entity Linking with Dense Entity Retrieval (2020.emnlp-main)

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Challenge: Existing methods for entity linking use manually curated mention tables and incoming Wikipedia link popularity.
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Virtual Knowledge Graph Construction for Zero-Shot Domain-Specific Document Retrieval (2022.coling-1)

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Challenge: Domain-specific documents cover terminologies and specialized knowledge.
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Zero-Shot Entailment Learning for Ontology-Based Biomedical Annotation Without Explicit Mentions (2025.coling-main)

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Challenge: Automated biomedical annotation presents significant challenges when entities are not explicitly mentioned in the text.
Approach: They propose an entailment-based zero-shot text classification approach to annotate biomedical text passages using the Homeostasis Imbalance Process (HOIP) ontology.
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Towards a Versatile Medical-Annotation Guideline Feasible Without Heavy Medical Knowledge: Starting From Critical Lung Diseases (2020.lrec-1)

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Challenge: Current annotation policies for medical corpora are not standardized across clinical texts of different types.
Approach: They propose to annotate medical records of various types using a named entity recognition (NER) task.
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Incorporating medical knowledge in BERT for clinical relation extraction (2021.emnlp-main)

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Challenge: Pre-trained language models (PLMs) are used for diverse NLP tasks such as Information Extraction, Sentiment Analysis and Question/Answering.
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Leveraging Type Descriptions for Zero-shot Named Entity Recognition and Classification (2021.acl-long)

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Challenge: Named entity recognition and classification (NERC) tasks require annotated data for the target classes during training.
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Knowledge-Rich Self-Supervision for Biomedical Entity Linking (2022.findings-emnlp)

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Challenge: Entity linking is challenging in high-value domains with myriad entities . standard classification approaches suffer from the annotation bottleneck .
Approach: They propose a self-supervised approach to learn domain knowledge for biomedical entity linking . it generates self-reported mention examples on unlabeled text and trains contextual encoder .
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Large language models are few-shot clinical information extractors (2022.emnlp-main)

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Challenge: a long-running goal of clinical NLP is the extraction of important variables trapped in clinical notes.
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