Challenge: Clinical trials require that patients meet eligibility criteria to ensure safety and effectiveness of studies.
Approach: They propose a dataset that includes the first-of-its-kind eligibility-criteria corpus and queries for criteria-to-sql . they propose 'neuro semantic parser' which can translate eligibility criteria to executable SQL queries .
Outcome: The proposed parser outperforms existing state-of-the-art general-purpose models while highlighting the challenges presented by the new dataset.

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Challenge: EHR-SeqSQL is the first text-to-SQl dataset to include sequential and contextual questions.
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CReSE: Benchmark Data and Automatic Evaluation Framework for Recommending Eligibility Criteria from Clinical Trial Information (2024.findings-eacl)

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Challenge: Eligibility criteria (EC) are defined as a set of conditions an individual must meet to participate in a clinical trial.
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Challenge: Despite recent advances, performance remains far from clinically reliable . specialized medical terminology and fine-grained temporal reasoning are key to executing clinical data analysis.
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Challenge: Large language models (LLMs) can generate natural language texts for various domains and tasks, but their potential for clinical text mining is under-explored.
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Recent Advances in Text-to-SQL: A Survey of What We Have and What We Expect (2022.coling-1)

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Challenge: text-to-SQL is a language processing and database-based language processing (NLP) task is to convert natural utterances into SQL queries and its practical application is to build natural language interfaces to database systems.
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Challenge: Eligibility criteria (EC) are critical components of clinical trial design, specifying parameters for participant inclusion and exclusion.
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FD-NL2SQL: Feedback-Driven Clinical NL2SQL that Improves with Use (2026.acl-demo)

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Challenge: Clinical trial databases are central to modern oncology research and drug development.
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Challenge: Existing methods that align natural language with SQL Language underestimate inherent structural characteristics of SQL and lead to structure errors.
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PARSQL: Enhancing Text-to-SQL through SQL Parsing and Reasoning (2025.findings-acl)

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Challenge: Large language models have made significant strides in text-to-SQL tasks, but small language models struggle to accurately interpret natural language questions due to resource limitations.
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EMRs2CSP : Mining Clinical Status Pathway from Electronic Medical Records (2025.findings-acl)

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Challenge: Current studies focus on extracting tests or treatments when constructing clinical pathways, neglecting the patient's symptoms and diagnosis.
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