Papers by Zhibin Duan
LipoAgent: Coordinating Fine-Tuned LLM Agents for Safer Lipid Design (2026.findings-acl)
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| Challenge: | Lipid nanoparticles (LNPs) are among the most clinically mature platforms for nucleic acid delivery, yet designing lipids that are effective and biologically safe remains a major bottleneck. |
| Approach: | They propose a safety-aware multi-agent LLM framework for lipid discovery that enforces toxicity as a prerequisite for efficiency prediction. |
| Outcome: | The proposed framework achieves an average improvement in mRNA transfection efficiency prediction across multiple foundation models. |
Friendly Topic Assistant for Transformer Based Abstractive Summarization (2020.emnlp-main)
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| Challenge: | Abstractive document summarization is a comprehensive task in natural language processing. |
| Approach: | They propose a topic assistant that rearranges and learns document semantics . they propose TA that is compatible with Transformer-based models and user-friendly . |
| Outcome: | The proposed model is compatible with Transformer-based models and user-friendly. |
EnsLM: Ensemble Language Model for Data Diversity by Semantic Clustering (2021.acl-long)
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| Challenge: | Existing studies have shown that data diversity affects the performance of LMs if we train a single LM over the entire dataset. |
| Approach: | They propose an autoencoding topic model with a mixture prior to perform clustering for the data. |
| Outcome: | The proposed model can learn knowledge from different samples while extracting cluster-specific features. |