Papers by Zongmin Zhao
LipoAgent: Coordinating Fine-Tuned LLM Agents for Safer Lipid Design (2026.findings-acl)
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| Challenge: | Lipid nanoparticles (LNPs) are among the most clinically mature platforms for nucleic acid delivery, yet designing lipids that are effective and biologically safe remains a major bottleneck. |
| Approach: | They propose a safety-aware multi-agent LLM framework for lipid discovery that enforces toxicity as a prerequisite for efficiency prediction. |
| Outcome: | The proposed framework achieves an average improvement in mRNA transfection efficiency prediction across multiple foundation models. |