Papers by Xiangzheng Fu
From Knowledge to Treatment: Large Language Model Assisted Biomedical Concept Representation for Drug Repurposing (2025.findings-emnlp)
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| Challenge: | Existing methods for drug repurposing ignore common-sense biomedical concept knowledge in real-world labs, such as mechanistic priors indicating that certain drugs are fundamentally incompatible with specific treatments. |
| Approach: | They propose a Large Language Model-assisted framework for Drug Repurposing which improves the representation of biomedical concepts within KGs. |
| Outcome: | The proposed framework improves the representation of biomedical concepts within KGs by extracting treatment-related textual representations of biomedic entities from large language models and fine-tuning knowledge graph embedding models. |
CAML: A Conflict-Aware Molecular Language Model Merging Framework for Multi-Constraint Molecular Generation (2026.acl-long)
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Xuanbai Ren, Luoda Tan, Pei Liu, Tengfei Ma, Xiangzheng Fu, Longyue Wang, Yiping Liu, Xiangxiang Zeng
| Challenge: | Existing paradigms struggle with this challenge due to catastrophic forgetting or gradient conflicts. |
| Approach: | They propose a conflict-aware molecular language model merging framework that generates multiple constraints moleculaire as a cooperative game among property-specific fine-tune models. |
| Outcome: | The proposed framework generates multiple constraints molecular as a cooperative game among property-specific fine-tune models (expert models) it minimizes conflicts among properties by exploring the optimal combination of the importance of the task parameter and relative fusion weights of each expert (fusion coefficient). |