Papers by Xiangxiang Zeng
POSITION BIAS MITIGATES POSITION BIAS: Mitigate Position Bias Through Inter-Position Knowledge Distillation (2025.emnlp-main)
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| Challenge: | Positional bias (PB) manifests as non-uniform sensitivity across contextual locations . previous studies have addressed PB by modifying the underlying architectures or employing extensive contextual awareness training. |
| Approach: | They propose a position-to-position knowledge distillation framework that leverages position-induced disparities to counteract PB. |
| Outcome: | The proposed framework reduces positional bias and improves performance on retrieval and reasoning tasks. |
M2PO: Multi-Perspective Multi-Pair Preference Optimization for Machine Translation (2026.acl-long)
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Hao Wang, Linlong Xu, Heng Liu, Yangyang Liu, Xiaohu Zhao, Bo Zeng, Liangying Shao, Yichen Dong, Xinwei Wu, Jiang Zhou, Tianyu Dong, Xiangxiang Zeng, Longyue Wang, Weihua Luo
| Challenge: | prevailing methods for machine translation are often hindered by misleading reward signals. |
| Approach: | They propose a framework that aligns large language models to human preferences . they propose 'M2PO' to correct the bias towards partial errors . |
| Outcome: | The proposed framework outperforms open-source models and achieves parity with proprietary models. |
Large Language and Protein Assistant for Protein-Protein Interactions Prediction (2025.acl-long)
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Peng Zhou, Pengsen Ma, Jianmin Wang, Xibao Cai, Haitao Huang, Wei Liu, Longyue Wang, Lai Hou Tim, Xiangxiang Zeng
| Challenge: | Existing methods for predicting protein-protein interactions oversimplify the problem of PPI prediction in a semi-supervised manner. |
| Approach: | They propose a multimodal large language model that integrates proteins and PPI networks. |
| Outcome: | Experiments show that LLaPA can predict protein-protein interactions (mPPI) types and affinities based on sequence data. |
From Knowledge to Treatment: Large Language Model Assisted Biomedical Concept Representation for Drug Repurposing (2025.findings-emnlp)
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| Challenge: | Existing methods for drug repurposing ignore common-sense biomedical concept knowledge in real-world labs, such as mechanistic priors indicating that certain drugs are fundamentally incompatible with specific treatments. |
| Approach: | They propose a Large Language Model-assisted framework for Drug Repurposing which improves the representation of biomedical concepts within KGs. |
| Outcome: | The proposed framework improves the representation of biomedical concepts within KGs by extracting treatment-related textual representations of biomedic entities from large language models and fine-tuning knowledge graph embedding models. |
CAML: A Conflict-Aware Molecular Language Model Merging Framework for Multi-Constraint Molecular Generation (2026.acl-long)
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Xuanbai Ren, Luoda Tan, Pei Liu, Tengfei Ma, Xiangzheng Fu, Longyue Wang, Yiping Liu, Xiangxiang Zeng
| Challenge: | Existing paradigms struggle with this challenge due to catastrophic forgetting or gradient conflicts. |
| Approach: | They propose a conflict-aware molecular language model merging framework that generates multiple constraints moleculaire as a cooperative game among property-specific fine-tune models. |
| Outcome: | The proposed framework generates multiple constraints molecular as a cooperative game among property-specific fine-tune models (expert models) it minimizes conflicts among properties by exploring the optimal combination of the importance of the task parameter and relative fusion weights of each expert (fusion coefficient). |