Papers by Haiyu Li
LipoAgent: Coordinating Fine-Tuned LLM Agents for Safer Lipid Design (2026.findings-acl)
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| Challenge: | Lipid nanoparticles (LNPs) are among the most clinically mature platforms for nucleic acid delivery, yet designing lipids that are effective and biologically safe remains a major bottleneck. |
| Approach: | They propose a safety-aware multi-agent LLM framework for lipid discovery that enforces toxicity as a prerequisite for efficiency prediction. |
| Outcome: | The proposed framework achieves an average improvement in mRNA transfection efficiency prediction across multiple foundation models. |
DRA-GRPO: Your GRPO Needs to Know Diverse Reasoning Paths for Mathematical Reasoning (2026.findings-acl)
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Xiwen Chen, Wenhui Zhu, Peijie Qiu, Xuanzhao Dong, Hao Wang, Haiyu Wu, Huayu Li, Aris Sotiras, Yalin Wang, Abolfazl Razi
| Challenge: | Existing methods for group-relative policy optimization rely on scalar correctness rewards that are often non-injective with respect to semantic content. |
| Approach: | They propose a framework that calibrates the reward signal using the semantic density of sampled groups. |
| Outcome: | The proposed framework outperforms strong baselines on five math benchmarks with 7,000 samples and 55 cost. |
GPS: Genetic Prompt Search for Efficient Few-Shot Learning (2022.emnlp-main)
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| Challenge: | Pretrained language models are often finetuned for downstream tasks, which has been shown to improve performance over non-pretrained models. |
| Approach: | They propose a genetic algorithm to automatically search for the best prompt for few-shot learning with pretrained language models by gradient-free algorithm. |
| Outcome: | Experiments on diverse datasets show that the proposed method outperforms manual prompts by 2.6 points. |
ZeroPrompt: Scaling Prompt-Based Pretraining to 1,000 Tasks Improves Zero-Shot Generalization (2022.findings-emnlp)
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| Challenge: | a recent study shows that task scaling can be an efficient alternative to model scaling. |
| Approach: | They propose a multitask pretraining approach ZeroPrompt for zero-shot generalization . they focus on task scaling and zero-shooting to improve model performance . |
| Outcome: | The proposed approach improves zero-shot generalization efficiency by 30 times with task scaling. |