Challenge: Drug safety research is crucial for maintaining public health, but resources available to the public are limited.
Approach: They propose an easy-to-use and interactive multi-source information visualisation platform for drug safety study.
Outcome: The proposed platform provides a one-stop information analysis, retrieval, and annotation service.

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PHEE: A Dataset for Pharmacovigilance Event Extraction from Text (2022.emnlp-main)

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Challenge: Using NLP methods to discover and extract adverse drug events from unstructured textual data is difficult because it requires time-consuming manual curation.
Approach: They propose to use a hierarchical event schema to extract annotated events from medical case reports and biomedical literature to analyze patient data.
Outcome: The proposed dataset is the largest public dataset to date and contains over 5000 events from medical case reports and biomedical literature.
A Dataset for N-ary Relation Extraction of Drug Combinations (2022.naacl-main)

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Challenge: Combination therapies are becoming standard of care for diseases such as cancer, tuberculosis, malaria and HIV.
Approach: They construct an expert-annotated dataset for extracting drug combinations from the scientific literature.
Outcome: The proposed dataset is the first relation extraction dataset consisting of variable-length relations.
BioDEX: Large-Scale Biomedical Adverse Drug Event Extraction for Real-World Pharmacovigilance (2023.findings-emnlp)

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Challenge: pharmacovigilance (PV) is a tool for analyzing adverse drug events from biomedical literature . pharmacologists use natural language processing to extract core information from papers .
Approach: They propose a resource for biomedical adverse drug event eXtraction using natural language processing.
Outcome: The proposed model achieves 59.1% F1 (validation) and estimates human performance to be 72.0% F1 . the proposed model could be used to improve drug safety monitoring, also called pharmacovigilance, in the future.
Enhancing Adverse Drug Event Detection with Multimodal Dataset: Corpus Creation and Model Development (2024.findings-acl)

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Challenge: ADEs are a serious public health concern and cost healthcare systems billions of dollars . despite advancements in healthcare, ADE detection remains a significant challenge .
Approach: They propose a multimodal adverse drug event detection dataset that merges ADE-related textual information with visual aids to enhance patient safety.
Outcome: The proposed dataset integrates ADE-related textual information with visual aids to improve patient safety and healthcare accessibility.
A Corpus of Drug Usage Guidelines Annotated with Type of Advice (L18-1)

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Challenge: Current research indicates patients are often unaware of such critical information / advice related to their prescription drugs due to lack of communication with their doctors and/or pharmacists.
Approach: They propose an annotation scheme for annotating safety critical advice from drug usage guidelines and an annotated dataset containing drug usage guideline data.
Outcome: The proposed dataset will accelerate further release of annotated drug usage guideline datasets and research on automatically filtering safety critical information from these documents.
Annotation of Adverse Drug Reactions in Patients’ Weblogs (2020.lrec-1)

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Challenge: Adverse drug reactions are a severe problem that significantly degrade quality of life and make the therapeutic approach unacceptable.
Approach: They crawled patient’s weblog articles shared on an online patient-networking platform and annotated the effects of drugs therein reported.
Outcome: The proposed dataset is unique for the richness of annotated information, including detailed descriptions of drug reactions with full context.
Decoding the Narratives: Analyzing Personal Drug Experiences Shared on Reddit (2024.findings-acl)

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Challenge: Our study aims to develop a multi-level, multi-label classification model to analyze online user-generated texts about substance use experiences.
Approach: They propose a taxonomy to assess the nature of posts, including intended connections (Inquisition or Disclosure), subjects (e.g., Recovery, Dependency), and specific objectives (eg. relapse, quality, safety).
Outcome: The proposed model outperforms other models on annotated data and shows that topics such as Safety, Combination of Substances, and Mental Health see more disclosure, while discussions about physiological Effects focus on harm reduction.
A Dataset for Pharmacovigilance in German, French, and Japanese: Annotating Adverse Drug Reactions across Languages (2024.lrec-main)

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Challenge: Existing clinical corpora mostly revolves around scientific articles in English . existing literature is limited to only a few scientific articles .
Approach: They propose to use user-generated data sources to uncover adverse drug reactions . existing clinical corpora mostly revolves around scientific articles in english . authors provide statistics to highlight certain challenges associated with the corpus .
Outcome: The proposed corpus includes 12 entity types, four attribute types, and 13 relation types . it provides strong baselines for extracting entities and relations between entities .
PharmaCoNER: Pharmacological Substances, Compounds and proteins Named Entity Recognition track (D19-57)

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Challenge: Biomedical text mining is one of the most prolific application domains of natural language processing technologies.
Approach: They propose to share a task on detecting drug and chemical entities in medical documents in Spanish with other languages to improve access to biomedical text mining.
Outcome: The first task on detecting drug and chemical entities in Spanish medical documents yielded competitive results with F-measures above 0.91.
Trialstreamer: Mapping and Browsing Medical Evidence in Real-Time (2020.acl-demos)

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Challenge: Trialstreamer extracts key pieces of information that clinicians need when appraising the literature . the highest-quality evidence to inform healthcare practice comes from randomized controlled trials .
Approach: They propose a system that extracts key pieces of information from biomedical abstracts and combines them into a database of clinical trial reports.
Outcome: The proposed system extracts descriptions of trial participants, treatments compared in each arm, and which outcomes were measured.

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