Challenge: Medical coding (MC) is an essential pre-requisite for reliable data retrieval and reporting.
Approach: They propose a method to classify medical terms into standardized alphanumerical terms and codes . they use a combination of traditional BERT-based classification and a zero/few-shot learning approach .
Outcome: The proposed approach outperforms baselines in the few-shot regime.

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MedCodER: A Generative AI Assistant for Medical Coding (2025.naacl-industry)

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Challenge: Medical coding is time-consuming and error-prone due to large label space, lengthy text inputs, and the absence of supporting evidence annotations.
Approach: They propose a Generative AI framework for automatic medical coding that leverages extraction, retrieval, and re-ranking techniques as core components.
Outcome: The proposed framework outperforms existing methods on the International Classification of Diseases (ICD) code prediction scale.
Extreme Zero-Shot Learning for Extreme Text Classification (2022.naacl-main)

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Challenge: Experimental results show that MACLR achieves superior performance compared to other baseline methods.
Approach: They propose to pre-train Transformer-based encoders with self-supervised contrastive losses to learn the semantic embeddings of instances and labels with raw text.
Outcome: The proposed method improves on the EZ-XMC model with a limited number of ground-truth positive pairs.
Large language models are few-shot clinical information extractors (2022.emnlp-main)

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Challenge: a long-running goal of clinical NLP is the extraction of important variables trapped in clinical notes.
Approach: They propose to use large language models to tackle diverse clinical extraction tasks . they propose to reannote existing CASI datasets to compare their models with clinical text.
Outcome: The proposed models outperform existing models on few-shot clinical information extraction tasks.
When Raw Data Prevails: Are Large Language Model Embeddings Effective in Numerical Data Representation for Medical Machine Learning Applications? (2024.findings-emnlp)

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Challenge: Numerical data is pivotal for medical questions and answers, but tabular data is not fully integrated into LLMs.
Approach: They examine the effectiveness of vector representations from last hidden states of LLMs for medical diagnostics and prognostics using electronic health record data.
Outcome: The proposed representations outperform those using raw numerical EHR data in medical diagnostics and prognostics.
Can Medical Vision-Language Pre-training Succeed with Purely Synthetic Data? (2025.findings-acl)

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Challenge: Medical Vision-Language Pretraining (MedVLP) models typically require large-scale datasets with paired, high-quality image-text data.
Approach: They propose to generate large-scale synthetic image-text pairs using off-the-shelf generative models . they propose to isolate model and training settings, focusing entirely from the data perspective.
Outcome: The proposed pipeline outperforms models trained on real data by 3.8% on averaged AUC on zero-shot classification tasks.
Just Read the Codebook! Make Use of Quality Codebooks in Zero-Shot Classification of Multilabel Frame Datasets (2025.coling-main)

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Challenge: Recent development of Large Language Models has led to more scrutiny of their performance on complex datasets.
Approach: They propose to use large language models to provide concise instructions on how to code text with a multitude of complex labels on two datasets with varying topics.
Outcome: The proposed approach outperforms few-shot In-Context-Learning setups on two complex datasets and is token-efficient and requires less hands-on engineering.
AutoMIR: Effective Zero-Shot Medical Information Retrieval without Relevance Labels (2025.findings-emnlp)

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Challenge: Effective zero-shot dense retrieval in the medical domain remains difficult due to the scarcity of relevance-labeled data.
Approach: They propose a framework that leverages large language models to generate hypothetical documents . they also propose 'CMIRB' to provide a rigorous evaluation suite .
Outcome: The proposed framework outperforms HyDE in retrieval accuracy and generalization . it leverages large language models to generate hypothetical documents conditioned on a query .
Zero-shot Medical Entity Retrieval without Annotation: Learning From Rich Knowledge Graph Semantics (2021.findings-acl)

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Challenge: Current approaches to medical entity retrieval generalize poorly to unseen sub-specialties . zero-shot retrieval is challenging due to the high degree of ambiguity and variability in medical corpora .
Approach: They propose a set of learning tasks designed to train efficient zero-shot entity retrieval models.
Outcome: The proposed architecture outperforms common zero-shot benchmarks with 7% to 30% higher recall across multiple major medical ontologies.
A Zero-shot and Few-shot Study of Instruction-Finetuned Large Language Models Applied to Clinical and Biomedical Tasks (2024.lrec-main)

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Challenge: Large Language Models (LLMs) have enabled advances in the field of natural language processing . however, their application and potential are still underexplored .
Approach: They evaluate four state-of-the-art instruction-tuned Large Language Models on 13 NLP tasks in English.
Outcome: The evaluated models outperform state-of-the-art models on 13 real-world clinical and biomedical NLP tasks in English.
Boosting Transformers and Language Models for Clinical Prediction in Immunotherapy (2023.acl-industry)

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Challenge: Current machine learning approaches to predict clinical outcomes are limited to tabular data and are not applicable to clinical prediction.
Approach: They investigate the potential of transformers to improve clinical prediction compared to conventional machine learning approaches and address the challenge of few-shot learning in predicting rare disease areas.
Outcome: The proposed model improves the accuracy of baseline models and language models under few-shot regimes and shows that it is more accurate than previous models.

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