Challenge: Relation extraction in the biomedical domain is challenging due to the lack of labeled data and high annotation costs.
Approach: They propose to use distant supervision to pair knowledge graph relationships with raw texts to tackle the scarcity of annotated data and to validate their results.
Outcome: The proposed benchmarks are more accurate and consistent with existing benchmarks and show that there is no train-test leakage.

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Challenge: Existing methods for extracting structured data from unstructured texts neglect unique features of the biomedical literature, such as ambiguous entities and nested proper nouns.
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Challenge: Existing biomedical IE benchmarks are narrow in scope and rely heavily on distantly supervised annotations.
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A Distant Supervision Corpus for Extracting Biomedical Relationships Between Chemicals, Diseases and Genes (2022.lrec-1)

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Challenge: Biomedical researchers have used manual curation to extract biomedical interactions from research texts to improve coverage.
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Syntax-aware Multi-task Graph Convolutional Networks for Biomedical Relation Extraction (D19-62)

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Challenge: 80% of the data sets for relation extraction tasks are negative instances, resulting in a lack of syntactic information between two entity mentions.
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Can NLI Provide Proper Indirect Supervision for Low-resource Biomedical Relation Extraction? (2023.acl-long)

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Challenge: Existing approaches to biomedical relation extraction (RE) are limited due to the scarcity of annotations and the prevalence of instances without explicitly pre-defined labels.
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Towards Accurate and Consistent Evaluation: A Dataset for Distantly-Supervised Relation Extraction (2020.coling-main)

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Challenge: Distant Supervision (DS) generates large-scale annotated data but has wrong labels that result in incorrect evaluation scores during testing.
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Dependency Parsing-Based Syntactic Enhancement of Relation Extraction in Scientific Texts (2025.findings-emnlp)

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Challenge: a pipeline approach to extract entities and relations from scientific text is challenging due to long sentences with densely packed entities.
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Global Relation Embedding for Relation Extraction (N18-1)

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Challenge: Existing methods to extract textual relations with distant supervision are limited by their reliance on supervised training data.
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What Do You Mean by Relation Extraction? A Survey on Datasets and Study on Scientific Relation Classification (2022.acl-srw)

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Challenge: Existing RE surveys focus on modeling techniques, but there are few that are based on real-world scenarios.
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Leveraging Dependency Forest for Neural Medical Relation Extraction (D19-1)

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Challenge: Existing methods for medical relation extraction use dependency syntax as a source of features.
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