Challenge: Automatic de-identification systems introduce errors due to their imperfect precision and may negatively impact the utility of the de-identified dataset.
Approach: They propose to de-identifie a large clinical corpus in Swedish by removing entire sentences containing sensitive data or by replacing sensitive words with realistic surrogates.
Outcome: The proposed models are safe to distribute to other academic researchers and reduce privacy risks.

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Data-Constrained Synthesis of Training Data for De-Identification (2025.acl-long)

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Challenge: sensitive domains lack widely available datasets due to privacy risks . recent studies have focused on evaluating the privacy of the synthetic text .
Approach: They domain-adapt LLMs to clinical domain and generate synthetic clinical texts . they then generate NER models that can be annotated with tags for PII .
Outcome: The proposed model performs better than the original model using smaller datasets.
Does BERT Pretrained on Clinical Notes Reveal Sensitive Data? (2021.naacl-main)

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Challenge: Pretraining large (masked) language models over EHR data has yielded consistent performance gains across tasks.
Approach: They propose to use large Transformers to release pretraining models over EHRs . they propose to recover patient names and conditions associated with them .
Outcome: The proposed models recover patient names and conditions associated with patients . the proposed models share the model parameters for use by other researchers .
Sensitive Data Detection and Classification in Spanish Clinical Text: Experiments with BERT (2020.lrec-1)

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Challenge: Massive digital data processing can endanger personal data privacy . anonymisation involves removing or replacing sensitive information from data .
Approach: They propose to use a BERT-based sequence labelling model to conduct an experiment on clinical datasets in Spanish.
Outcome: The proposed model outperforms existing models on clinical datasets in Spanish and shows that it is highly competitive with other models.
Towards Fair and Efficient De-identification: Quantifying the Efficiency and Generalizability of De-identification Approaches (2026.findings-eacl)

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Challenge: a recent study has not examined their generalizability between formats, cultures, and genders.
Approach: They evaluate large language models (LLMs) and small LLMs at clinical de-identification . they show that smaller models achieve comparable performance while substantially reducing inference cost .
Outcome: The proposed models outperform larger models in de-identification tasks with limited data . the models can be fine-tuned with limited datasets to outperformed larger models .
Impact of Training Instance Selection on Domain-Specific Entity Extraction using BERT (2022.naacl-srw)

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Challenge: Named entity recognition (NER) tasks require a large number of training examples and handcrafted features.
Approach: They propose to fine-tune pre-trained language models such as BERT to achieve up to 80% F1 when fine- tuned on only 70 training examples.
Outcome: The proposed model achieves 80% F1 when fine-tuned on only 70 training examples, especially on biomedical domain.
Evaluating Pretraining Strategies for Clinical BERT Models (2022.lrec-1)

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Challenge: Existing generic language models in specialized domains may be sub-optimal due to domain differences.
Approach: They propose various strategies for adapting a generic language model to the target domain and various forms of vocabulary modifications to fine-tune it.
Outcome: The proposed strategies outperform a general-domain language model but little difference in performance between the models.
Re-train or Train from Scratch? Comparing Pre-training Strategies of BERT in the Medical Domain (2022.lrec-1)

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Challenge: Recent years have witnessed the widespread use of transfer learning techniques in Natural Language Processing (NLP)
Approach: They train BERT models from scratch using many configurations involving general and medical corpora.
Outcome: The initial corpus only has a weak influence when these are further pre-trained on a medical corpus.
Closing the Gap: Joint De-Identification and Concept Extraction in the Clinical Domain (2020.acl-main)

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Challenge: Recent studies show that de-identification is effective in the clinical domain but not in the downstream tasks.
Approach: They propose a stacked model with restricted access to privacy sensitive information and a multitask model to investigate the effect of de-identification on clinical concept extraction.
Outcome: The proposed model is stacked with restricted access to privacy sensitive information and a multitask model.
Incorporating medical knowledge in BERT for clinical relation extraction (2021.emnlp-main)

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Challenge: Pre-trained language models (PLMs) are used for diverse NLP tasks such as Information Extraction, Sentiment Analysis and Question/Answering.
Approach: They propose to add medical knowledge to pre-trained language models to facilitate clinical relation extraction using a large text corpus.
Outcome: The proposed model outperforms the state-of-the-art systems on the benchmark i2b2/VA 2010 clinical relation extraction dataset.
How Far Is Too Far? Studying the Effects of Domain Discrepancy on Masked Language Models (2024.lrec-main)

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Challenge: Pre-trained masked language models perform strongly on a wide variety of NLP tasks.
Approach: They propose a mechanism to quantify the difference in domains between the pre-trained model and the task and partition it using a cloze task.
Outcome: The proposed model performs better on openly available e-commerce datasets than the original model on scientific and biomedical datasets.

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