Challenge: Recent studies show that cognitive manifestations of future dementia may appear as early as 18 years prior to clinical diagnosis . lack of clear diagnosis and prognosis, possibly for an Alzheimer's type, is a major limitation of current methods for identifying dementia-specific cognitive markers.
Approach: They propose to interrogate neural LMs trained on participants with and without dementia by manipulating lexical frequency.
Outcome: The proposed model improves upon the current state-of-the-art for models trained on transcripts of speech produced by healthy participants and those with dementia.

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Too Big to Fail: Larger Language Models are Disproportionately Resilient to Induction of Dementia-Related Linguistic Anomalies (2024.findings-acl)

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Challenge: Existing studies show that the attention mechanism in transformer-based NLMs may present an analogue to the notions of cognitive and brain reserve.
Approach: They propose a bidirectional ablation method that masks attention heads to display degradation of similar magnitude to masking in smaller models.
Outcome: The proposed method exhibits properties attributed to the concepts of cognitive and brain reserve in human brain studies.
GPT-D: Inducing Dementia-related Linguistic Anomalies by Deliberate Degradation of Artificial Neural Language Models (2022.acl-long)

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Challenge: Existing methods for fine-tuning large numbers of model parameters have shown impressive performance on the task of discriminating between language produced by cognitively healthy individuals and those with Alzheimer’s disease (AD).
Approach: They propose to use a Transformer DL model pre-trained on general English text to combine an artificially degraded version of itself with a model that generalizes well to spontaneous conversations.
Outcome: The proposed method generalizes well to spontaneous conversations and generates text with characteristics associated with AD, demonstrating the induction of dementia-related linguistic anomalies.
Enriching Neural Models with Targeted Features for Dementia Detection (P19-2)

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Challenge: In the United States, adults over 65 are expected to comprise one-fifth of the population by 2030, and a larger proportion of the . population than those under 18 by 2035.
Approach: They propose a neural model that takes into account both long language samples and hand-crafted linguistic features to distinguish between dementia affected and healthy patients.
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Detecting Linguistic Characteristics of Alzheimer’s Dementia by Interpreting Neural Models (N18-2)

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Challenge: Current diagnoses often involve lengthy medical evaluations.
Approach: They apply neural models based on CNNs, LSTM-RNNs, and their combination to classify AD and control language samples.
Outcome: The proposed model achieves independent benchmark accuracy for the AD classification task.
Dementia Through Different Eyes: Explainable Modeling of Human and LLM Perceptions for Early Awareness (2025.findings-emnlp)

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Challenge: a new study examines how dementia is perceived by non-experts . human perception of dementia is inconsistent and relies on a narrow set of cues compared to LLMs based on broader clinical patterns .
Approach: They propose a method that uses LLMs to extract high-level, expert-guided features . human perception of dementia is inconsistent and relies on a narrow set of cues, they say .
Outcome: The proposed method analyzes picture descriptions to assess whether they were produced by non-experts or by nonexperts.
Multilingual prediction of Alzheimer’s disease through domain adaptation and concept-based language modelling (N19-1)

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Challenge: Existing work on speech and language models has been limited by the size of available datasets.
Approach: They propose to augment a small French dataset with a much larger English dataset to augment the language model to model the order in which information units are produced by dementia patients and controls.
Outcome: The proposed model improves classification performance in English and French separately.
Context Limitations Make Neural Language Models More Human-Like (2022.emnlp-main)

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Challenge: Language models (LMs) have been used in cognitive modeling and engineering studies to simulate human cognitive load during reading.
Approach: They propose to constrain LMs' context access to improve their simulation of human reading behavior by incorporating syntactic biases into their context access.
Outcome: The proposed model improves the simulation of human reading behavior by incorporating syntactic biases into their context access.
Language Model Evaluation Beyond Perplexity (2021.acl-long)

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Challenge: a nascent literature on probing language models has focused on studying linguistic phenomena.
Approach: They propose a framework for evaluating the fit of language models to natural language tendencies.
Outcome: The proposed framework evaluates language models to the tendencies of natural language . it shows that the models learn only a subset of the tendancies considered .
Mapping Brains with Language Models: A Survey (2023.findings-acl)

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Challenge: accumulated evidence for brain and language model activations remains ambiguous, but correlations with model size and quality provide grounds for cautious optimism.
Approach: They examine the evidence accumulated by 30 studies spanning 10 datasets and 8 metrics to determine whether there is any overlap between brain and language model activations.
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Speech language models lack important brain-relevant semantics (2024.acl-long)

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Challenge: Recent work shows that text-based language models predict both text- and speech-evoked brain activity.
Approach: They remove low-level stimulus features from language models to assess their impact on alignment with fMRI brain recordings during reading and listening.
Outcome: The proposed model removes low-level features from fMRI brain recordings to assess their impact on alignment with fmr recordings.

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