Detecting Adverse Drug Reactions from Biomedical Texts with Neural Networks (P19-2)

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Challenge: Detection of adverse drug reactions in post-marketing period is a crucial challenge for pharmacology.
Approach: They propose to use social media to extract information about adverse drug reactions . they compare four state-of-the-art attention-based neural networks to the F-measure .
Outcome: The proposed methods perform better on four different benchmarks.

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Annotation of Adverse Drug Reactions in Patients’ Weblogs (2020.lrec-1)

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Challenge: Adverse drug reactions are a severe problem that significantly degrade quality of life and make the therapeutic approach unacceptable.
Approach: They crawled patient’s weblog articles shared on an online patient-networking platform and annotated the effects of drugs therein reported.
Outcome: The proposed dataset is unique for the richness of annotated information, including detailed descriptions of drug reactions with full context.
Knowledge-augmented Graph Neural Networks with Concept-aware Attention for Adverse Drug Event Detection (2024.lrec-main)

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Challenge: Recent studies have used word embedding and deep learning to automate ADE detection from text, but they did not incorporate explicit medical knowledge about drugs and adverse reactions or the corresponding feature learning.
Approach: They propose to integrate medical knowledge into ADE detection from text . they use contextualized embeddings from pretrained language models and convolutional graph neural networks to learn features differently for different types of nodes in the graph.
Outcome: The proposed model outperforms existing models on four public datasets and shows that it is based on medical knowledge and embeddings from pretrained language models and neural networks.
A Dataset for Pharmacovigilance in German, French, and Japanese: Annotating Adverse Drug Reactions across Languages (2024.lrec-main)

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Challenge: Existing clinical corpora mostly revolves around scientific articles in English . existing literature is limited to only a few scientific articles .
Approach: They propose to use user-generated data sources to uncover adverse drug reactions . existing clinical corpora mostly revolves around scientific articles in english . authors provide statistics to highlight certain challenges associated with the corpus .
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Cross-lingual Approaches for the Detection of Adverse Drug Reactions in German from a Patient’s Perspective (2022.lrec-1)

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Challenge: a recent study shows that the class labels of german documents containing ADRs are imbalanced . clinical trials and physicians prescribing medications cannot cover every potential use case.
Approach: They propose to use binary annotated documents from a german patient forum to detect ADRs.
Outcome: The proposed model achieves an F1 score of 37.52 for the positive class on the German patient forum.
BioDEX: Large-Scale Biomedical Adverse Drug Event Extraction for Real-World Pharmacovigilance (2023.findings-emnlp)

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Challenge: pharmacovigilance (PV) is a tool for analyzing adverse drug events from biomedical literature . pharmacologists use natural language processing to extract core information from papers .
Approach: They propose a resource for biomedical adverse drug event eXtraction using natural language processing.
Outcome: The proposed model achieves 59.1% F1 (validation) and estimates human performance to be 72.0% F1 . the proposed model could be used to improve drug safety monitoring, also called pharmacovigilance, in the future.
PHEE: A Dataset for Pharmacovigilance Event Extraction from Text (2022.emnlp-main)

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Challenge: Using NLP methods to discover and extract adverse drug events from unstructured textual data is difficult because it requires time-consuming manual curation.
Approach: They propose to use a hierarchical event schema to extract annotated events from medical case reports and biomedical literature to analyze patient data.
Outcome: The proposed dataset is the largest public dataset to date and contains over 5000 events from medical case reports and biomedical literature.
Enhancing Drug-Drug Interaction Extraction from Texts by Molecular Structure Information (P18-2)

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Challenge: Graph Convolutional Networks (GCNs) can extract drug-drug interactions (DDIs) from texts using external drug molecular structure information.
Approach: They propose a novel neural method to extract drug-drug interactions (DDIs) from texts using external drug molecular structure information.
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Enhancing Adverse Drug Event Detection with Multimodal Dataset: Corpus Creation and Model Development (2024.findings-acl)

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Challenge: ADEs are a serious public health concern and cost healthcare systems billions of dollars . despite advancements in healthcare, ADE detection remains a significant challenge .
Approach: They propose a multimodal adverse drug event detection dataset that merges ADE-related textual information with visual aids to enhance patient safety.
Outcome: The proposed dataset integrates ADE-related textual information with visual aids to improve patient safety and healthcare accessibility.
Medical Sentiment Analysis using Social Media: Towards building a Patient Assisted System (L18-1)

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Challenge: a study conducted by the pew Internet & American Life Project 1 shows that almost 80 percent of Internet users have explored health-related topic online.
Approach: They propose to crawl medical forums with opinions about medical condition self narrated by users.
Outcome: The proposed system is based on opinions about medical condition self-narrated by users on medical forums.
Training Data Augmentation for Detecting Adverse Drug Reactions in User-Generated Content (D19-1)

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Challenge: Existing dictionary-based, semi-supervised learning approaches are limited by the coverage and maintainability of laymen health vocabularies.
Approach: They propose a data augmentation approach that leverages variational autoencoders to learn high-quality data distributions from a large unlabeled dataset and generate a small set of labeled training sets.
Outcome: The proposed approach matches the performance of fully-supervised approaches while requiring only 25% of training data.

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