Challenge: Large language models (LLMs) are a promising way to bridge the gap between patient health literacy and access to care.
Approach: They evaluate a range of open- and closed-source LLMs on a MeDiSumQA dataset . they propose a lightweight multi-agent framework for patient-oriented medical question answering .
Outcome: The proposed model achieves lower FKGL than zero-shot GPT-5 and highest simplification quality among all models.

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Challenge: Existing Med-MLLMs fail when deployed in low-resource settings where abundant labeled data is unavailable.
Approach: They propose a training-free agentic framework that performs medical knowledge augmentation via LLM agents.
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Med-MoE: Mixture of Domain-Specific Experts for Lightweight Medical Vision-Language Models (2024.findings-emnlp)

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Challenge: Recent advances in multimodal large language models have seen remarkable progress for medical decision-making, however, they are designated for specific classification or generative tasks and require model training or finetuning on large-scale datasets with sizeable parameters and tremendous computing.
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Agentic Medical Knowledge Graphs Enhance Medical Question Answering: Bridging the Gap Between LLMs and Evolving Medical Knowledge (2025.findings-emnlp)

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Challenge: Large Language Models have greatly advanced medical Question Answering (QA) however, the rapid evolution of medical knowledge and manual updating of domain-specific resources can undermine reliability of these systems.
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MedLogic-AQA: Enhancing Medicare Question Answering with Abstractive Models Focusing on Logical Structures (2024.findings-emnlp)

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Challenge: Existing question-answering systems struggle to capture intricate logical structures and relationships inherent in medical contexts, thus limiting their capacity to furnish precise and nuanced answers.
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MATA: Multi-Agent Framework for Reliable and Flexible Table Question Answering (2026.findings-acl)

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Challenge: Recent advances in Large Language Models have significantly improved table understanding tasks . practical deployment of TableQA systems presents several persistent challenges .
Approach: They propose a multi-agent TableQA framework that leverages multiple reasoning paths and tools built with small language models.
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What Does Infect Mean to Cardio? Investigating the Role of Clinical Specialty Data in Medical LLMs (2026.eacl-long)

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Challenge: S-MedQA is an English question-answering dataset designed for benchmarking large language models in fine-grained clinical specialties.
Approach: They propose to use an English medical question-answering dataset to benchmark large language models in clinical specialties.
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MedREQAL: Examining Medical Knowledge Recall of Large Language Models via Question Answering (2024.findings-acl)

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Challenge: Large language models can encode knowledge during pre-training on large text corpora, enabling downstream tasks like question answering (QA).
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Medical Question Understanding and Answering with Knowledge Grounding and Semantic Self-Supervision (2022.coling-1)

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Challenge: Current medical question answering systems have difficulty processing long, detailed and informally worded questions . a growing number of approaches attempt to enhance the processing of consumer health questions - or medical question understanding .
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MED-COPILOT: A Medical Assistant Powered by GraphRAG and Similar Patient Case Retrieval (2026.acl-demo)

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Challenge: MED-COPILOT is an interactive research prototype for evidence-aware clinical reasoning . large language models (LLMs) are prone to hallucinations and lack verifiable evidence grounding .
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A Survey of LLM-based Agents in Medicine: How far are we from Baymax? (2025.findings-acl)

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Challenge: Large Language Models (LLMs) are transforming healthcare through their ability to understand and assist with medical tasks.
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