Challenge: Manual assignment of ATC codes to prescription records is a significant bottleneck in healthcare operations.
Approach: They propose a method to automate the assignment of ATC codes to prescription records . they use locally deployable large language models to guide LLMs through the ontology .
Outcome: The proposed method achieves 78% exact match accuracy with GPT-4o and 60% with Llama 3.1 70B.

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Challenge: Existing methods for clinical code verification fail to account for hierarchical misalignments . standardized coding systems such as ICD-10-CM1 ensure consistency across medical records.
Approach: They propose to use prompt engineering and small-scale fine-tuning to improve accuracy without the computational overhead of search-based methods.
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ICDAGENT: Empowering Agentic Large Language Models for Explainable Medical Coding (2026.acl-long)

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Challenge: Existing models lack convincing, human-understandable explanations, making them difficult for physicians to trust and use in practice.
Approach: They propose a framework that aims to automatically assign ICD codes to clinical notes while providing explicit justifications for each assignment.
Outcome: The proposed framework achieves effective ICD coding with accurate explanations using two collaborative LLM agents: a coding agent and a critical agent.
Distributed Knowledge Based Clinical Auto-Coding System (P19-2)

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Challenge: Codification of free-text clinical narratives has long been recognised to be beneficial for secondary uses such as funding, insurance claim processing and research.
Approach: They propose to use NLP and related machine learning techniques to assign ICD-10-AM and ACHI codes to clinical records using local and international standards.
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Beyond Label Attention: Transparency in Language Models for Automated Medical Coding via Dictionary Learning (2024.emnlp-main)

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Challenge: Current efforts in interpretability of medical coding rely heavily on label attention mechanisms, which often leads to the highlighting of extraneous tokens irrelevant to the ICD code.
Approach: They propose to leverage dictionary learning to extract sparsely activated representations from dense language models embedded in superposition to facilitate accurate interpretability.
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Towards Adapting Open-Source Large Language Models for Expert-Level Clinical Note Generation (2025.findings-acl)

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Challenge: Proprietary Large Language Models (LLMs) have demonstrated promising capabilities in clinical text summarization tasks.
Approach: They propose a domain- and task-specific adaptation process for an open-source LLaMA-2 model . LLama-2 can generate high-quality clinical notes from outpatient patient-doctor dialogues .
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Empowering Healthcare Practitioners with Language Models: Structuring Speech Transcripts in Two Real-World Clinical Applications (2025.emnlp-industry)

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Challenge: Large language models (LLMs) have demonstrated strong performance on clinical natural language processing tasks across multiple medical benchmarks.
Approach: They propose an agentic pipeline for generating realistic, non-sensitive nurse dictations, enabling structured extraction of clinical observations.
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From Scores to Steps: Diagnosing and Improving LLM Performance in Evidence-Based Medical Calculations (2025.emnlp-main)

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Challenge: Existing benchmarks assess only the final answer with a wide numerical tolerance, overlooking systematic reasoning failures and potentially causing serious clinical misjudgments.
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LlamaCare: An Instruction Fine-Tuned Large Language Model for Clinical NLP (2024.lrec-main)

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Challenge: Large language models have shown remarkable abilities in generating natural texts . applying LLMs to clinical domain still poses significant challenges .
Approach: They propose a method of instruction fine-tuning for adapting large language models to clinical domains . they generate instructions, inputs, and outputs covering a wide spectrum of clinical services .
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Clinical-Coder: Assigning Interpretable ICD-10 Codes to Chinese Clinical Notes (2020.acl-demos)

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Challenge: Existing methods of automatic coding prediction have been successful, but the interpretability of predicted codes is a challenge.
Approach: They propose an online system that can predict ICD codes for Chinese clinical notes by using a Dilated Convolutional Attention network with N-gram Matching mechanism.
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Towards Injecting Medical Visual Knowledge into Multimodal LLMs at Scale (2024.emnlp-main)

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Challenge: Multimodal large language models (MLLMs) lack visual knowledge in medical applications due to data privacy concerns and high annotation costs.
Approach: They refined medical image-text pairs from PubMed and employed MLLMs (GPT-4V) to denoise and reformat the data.
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