Challenge: Effective domain adaptation typically involves supervised fine-tuning on carefully selected instruction-tuned data.
Approach: They propose a model-centric data selection framework that aligns data selection with the model’s knowledge distribution to improve model performance.
Outcome: The proposed framework outperforms existing methods by up to 2.97% accuracy in the healthcare domain.

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Challenge: Large Language Models (LLMs) have revolutionized natural language processing, but their success remains limited to high-resource domains.
Approach: They analyze the coverage and representativeness of specialized-domain QA datasets against large-scale reference datasets.
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Exploring LLM Annotation for Adaptation of Clinical Information Extraction Models under Data-sharing Restrictions (2025.findings-acl)

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Challenge: In-hospital text data often contains valuable clinical information, yet fine-tuned small language models (SLMs) for information extraction remain challenging due to differences in formatting and vocabulary across institutions.
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DaMoC: Efficiently Selecting the Optimal Large Language Model for Fine-tuning Domain Tasks Based on Data and Model Compression (2025.findings-emnlp)

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Challenge: Large language models excel in general tasks but struggle with domain-specific ones, requiring fine-tuning with specific data.
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Take the essence and discard the dross: A Rethinking on Data Selection for Fine-Tuning Large Language Models (2025.naacl-long)

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Challenge: Existing studies focus on data selection but lack a clear, unified framework . variability in experimental settings complicates systematic comparisons .
Approach: They propose a three-stage scheme to standardize data selection for fine-tuning large language models . they propose unified comparison approach that incorporates ratio-based efficiency and ranking-based feasibility metrics to address inconsistencies across experiments.
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Injecting Domain-Specific Knowledge into Large Language Models: A Comprehensive Survey (2025.findings-emnlp)

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Challenge: specialized LLMs are often limited in domain-specific applications that require specialized knowledge.
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Fact Finder - Enhancing Domain Expertise of Large Language Models by Incorporating Knowledge Graphs (2026.eacl-demo)

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Challenge: Recent advances in Large Language Models have demonstrated their proficiency in answering natural language queries.
Approach: They propose a system that augments Large Language Models with domain-specific knowledge graphs . they evaluate a medical KG and use a KG-based retrieval approach to enhance factual correctness .
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Reformulating Domain Adaptation of Large Language Models as Adapt-Retrieve-Revise: A Case Study on Chinese Legal Domain (2024.findings-acl)

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Challenge: Recent large language models like GPT-4 have demonstrated astonishing zero-shot capabilities in general domain tasks, but they often generate content with hallucinations in specific domains such as Chinese law.
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The Data Frontier for Large Language Models: Selection, Synthesis, and Tools (2026.acl-tutorials)

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Challenge: acquiring and curating high-quality training data remains a significant bottleneck . acquiring such high-quality data is a key challenge for researchers and practitioners .
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Improving the OOD Performance of Closed-Source LLMs on NLI Through Strategic Data Selection (2026.findings-eacl)

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Challenge: Existing methods to improve robustness require changing the fine-tuning process or large-scale data augmentation, which are infeasible or cost prohibitive for closed-source models.
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Adaptation of Large Language Models (2025.naacl-tutorial)

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Challenge: a tutorial on adaptation of large language models addresses the growing demand for models that go beyond static capabilities.
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