Challenge: Medical Visual Question Answering (Med-VQA) aims to provide accurate answers to questions regarding medical images, a task particularly challenging for open-ended questions.
Approach: They propose a multi-modal concept alignment pre-training approach for generative Med-VQA that leverages a knowledge graph sourced from medical image-caption datasets and the Unified Medical Language System.
Outcome: The proposed approach significantly outperforms existing methods on a set of benchmark datasets and shows high efficiency and knowledge-image alignment capability.

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Challenge: Existing models for medical visual question answering are limited in their interpretation and interpretation . a semi-automated annotation process is used to streamline data preparation and build new benchmark datasets .
Approach: They propose a semi-automated annotation process to streamline data preparation and build new benchmark Med-VQA datasets.
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Open-Ended Visual Question Answering by Multi-Modal Domain Adaptation (2020.findings-emnlp)

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Challenge: Existing approaches to visual question answering (VQA) are not suitable for real-world applications.
Approach: They propose a supervised multi-modal domain adaptation method for visual question answering in images that exploits supervised domain adaptation.
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MLeVLM: Improve Multi-level Progressive Capabilities based on Multimodal Large Language Model for Medical Visual Question Answering (2024.findings-acl)

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Challenge: Existing MVQA models ignore multi-level progressive capabilities due to unspecific data and plain architecture.
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Seeing Beyond: Enhancing Visual Question Answering with Multi-Modal Retrieval (2025.coling-industry)

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Challenge: Multi-modal Large language models still suffer from model hallucination and lack of specific knowledge when answering challenging questions.
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Seeing Is Believing! towards Knowledge-Infused Multi-modal Medical Dialogue Generation (2024.lrec-main)

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Challenge: Existing models of disease diagnosis using AI do not use knowledge infusion.
Approach: They propose a transformer-based, knowledge-infused multi-modal medical dialogue generation framework . they propose 'discourse-aware' image identifier that recognizes signs and their severity .
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MedEx: Enhancing Medical Question-Answering with First-Order Logic based Reasoning and Knowledge Injection (2025.coling-main)

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Challenge: Existing knowledge triples are ineffective in medical question-answering because of superfluous data and inability to capture complex relationships between symptoms and treatments.
Approach: They propose a first-order logical reasoning model that uses First-Order Logic to model intricate relationships between diseases and treatments.
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Cross-Modal Retrieval Augmentation for Multi-Modal Classification (2021.findings-emnlp)

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Challenge: Recent advances in using retrieval components over external knowledge sources have shown impressive results for a variety of downstream tasks in natural language processing.
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Mulan: A Multi-Level Alignment Model for Video Question Answering (2023.findings-emnlp)

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Challenge: Existing methods focus on visual-language alignment at the video level, but they do not account for fine-grained semantic interaction between video and text.
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In Factuality: Efficient Integration of Relevant Facts for Visual Question Answering (2021.acl-short)

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Challenge: Current Visual Question Answering (VQA) models are trained on labelled data that may be insufficient to learn complex knowledge representations.
Approach: They propose a method to integrate external knowledge into a visual pre-trained model by integrating facts extracted from a knowledge base.
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Med-MoE: Mixture of Domain-Specific Experts for Lightweight Medical Vision-Language Models (2024.findings-emnlp)

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Challenge: Recent advances in multimodal large language models have seen remarkable progress for medical decision-making, however, they are designated for specific classification or generative tasks and require model training or finetuning on large-scale datasets with sizeable parameters and tremendous computing.
Approach: They propose a framework that tackles discriminative and generative multimodal medical tasks using multimodal alignment, instruction tuning and routing.
Outcome: The proposed model can achieve superior performance to or on par with state-of-the-art baselines while only requiring 30%-50% of activated model parameters.

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