Challenge: Existing methods focused on time series data but ignored clinical notes . fusion of multi-modal features of patients from different views is not feasible due to the time series and clinical notes data being stored as time series.
Approach: They propose to combine time series and clinical notes to fuse multi-modal features of patients from different perspectives using graph neural networks.
Outcome: The proposed method is superior to existing models on MIMIC-III benchmark.

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How to leverage the multimodal EHR data for better medical prediction? (2021.emnlp-main)

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Challenge: Using deep learning to improve healthcare is challenging due to the complexity of EHR data.
Approach: They propose a method to integrate clinical notes from EHR and combine them with different data to improve prediction performance.
Outcome: The proposed model outperforms the state-of-the-art method without clinical notes on two prediction tasks.
Data Drift in Clinical Outcome Prediction from Admission Notes (2024.lrec-main)

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Challenge: a pivotal dataset for clinical NLP research was released in 2016 . public access to such datasets is limited due to privacy and ethical concerns .
Approach: They propose a novel clinical outcome prediction dataset based on MIMIC-IV . they provide initial insights into the performance of models trained on MIDIC-III .
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LIFTED: Multimodal Clinical Trial Outcome Prediction via Large Language Models and Mixture-of-Experts (2025.findings-emnlp)

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Challenge: Clinical trials are costly and pivotal processes that require substantial expenses . a new approach to integrate multimodal data for clinical outcome prediction is needed .
Approach: a proposed framework transforms modality-specific data into natural language descriptions . a sparse Mixture-of-Experts mechanism then identifies shared patterns across modalities .
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Patient Outcome and Zero-shot Diagnosis Prediction with Hypernetwork-guided Multitask Learning (2023.eacl-main)

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Challenge: Recent advances apply artificial intelligence to predict clinical events or infer the probable diagnosis for clinical decision support.
Approach: They propose a hypernetwork-based approach that generates task-conditioned parameters and coefficients of multitask prediction heads to learn task-specific prediction and balance the multitask learning.
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Clinical Outcome Prediction from Admission Notes using Self-Supervised Knowledge Integration (2021.eacl-main)

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Challenge: Clinical decision support systems can help in situations where the patient's development is predicted based on textual data.
Approach: They propose to use clinical outcome pre-training to integrate knowledge about patient outcomes from multiple public sources into the models.
Outcome: The proposed model improves performance against several baselines and demonstrates that it is transferable and can be used in clinical decision support systems.
Literature-Augmented Clinical Outcome Prediction (2022.findings-naacl)

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Challenge: Existing approaches to clinical outcome prediction use only clinical notes and general biomedical literature.
Approach: They propose to retrieve patient-specific medical literature and incorporate it into predictive models by combining clinical notes with language models.
Outcome: The proposed approach boosts predictive performance on three important clinical tasks in comparison to strong LM baselines, increasing F1 by up to 5 points and precision@Top-K by a large margin of over 25%.
Seeing Is Believing! towards Knowledge-Infused Multi-modal Medical Dialogue Generation (2024.lrec-main)

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Challenge: Existing models of disease diagnosis using AI do not use knowledge infusion.
Approach: They propose a transformer-based, knowledge-infused multi-modal medical dialogue generation framework . they propose 'discourse-aware' image identifier that recognizes signs and their severity .
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Attention Networks for Augmenting Clinical Text with Support Sets for Diagnosis Prediction (2022.coling-1)

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Challenge: Clinical language models may suffer from imbalanced vocabulary for describing diseases or symptoms.
Approach: They propose to augment clinical text with potentially complementary diagnostic codes from prior admissions or as they emerge during differential diagnosis to improve the performance.
Outcome: The proposed approach outperforms the previous state-of-the-art PubMedBERT by up 3% points.
Causal Representation Learning from Multimodal Clinical Records under Non-Random Modality Missingness (2025.emnlp-main)

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Challenge: Clinical notes are often missing from clinical notes, resulting in modality missing-not-at-random (MMNAR) . large language models fine-tuned or adapted to clinical tasks have shown promise in medical reasoning, outcome prediction, and decision support.
Approach: They propose a framework that leverages observed data and informative missingness in multimodal clinical records.
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Clinical Note Owns its Hierarchy: Multi-Level Hypergraph Neural Networks for Patient-Level Representation Learning (2023.acl-long)

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Challenge: Clinical notes of patient EHRs contain valuable information from healthcare professionals, but have been underutilized due to their difficult-to-understand contents and complex hierarchies.
Approach: They propose to use clinical notes to learn more balanced knowledge from EHRs by assembling useful neutral words with rare keywords via note and taxonomy level hyperedges.
Outcome: The proposed method can retain clinical semantic information by (1) frequent neutral words and (2) hierarchies with imbalanced distribution.

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